{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:43:20Z","timestamp":1792827800885,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sporotrichosis is a subcutaneous mycosis caused by a dimorphic fungus belonging to the genus <jats:italic>Sporothrix<\/jats:italic>. This fungal infection can affect both humans and domestic animals, and in recent years, an increase in the geographic spread and prevalence of sporotrichosis has been observed globally. This systematic review aimed to examine the clinical\u2010epidemiological and therapeutic aspects related to sporotrichosis co\u2010infection with human immunodeficiency virus (HIV)\/acquired immunodeficiency syndrome (AIDS). An extensive electronic search was conducted on databases including PubMed, Web of Science, Lilacs, Medline, Embase, Scopus and SciELO was performed to identify clinical cases of people living with HIV (PLWH) with sporotrichosis published until May 2023. As a result, we found that most co\u2010infected patients were male, representing 71.76% (94\/131) of cases. The most prevalent age group was 41\u201350\u2009years, with a mean age of 36.98\u2009years. The countries with the highest number of cases were Brazil (75.57%, 99\/131) and the United States (16.03%, 21\/131). The most frequent clinical presentation was systemic dissemination, accounting for 69.47% (91\/131) of the cases, followed by cutaneous dissemination with 13% (17\/131). The mean CD4<jats:sup>+<\/jats:sup> cell count was 154.07 cells\/\u03bcL, and most patients used amphotericin B with at least one azole, which represented 47.33% (62\/131) of cases, followed by azole monotherapy in 17.56% (23\/131) of cases. As for the outcome, 51.15% (67\/131) of the patients remained alive, and 37.4% (49\/131) died. Therefore, it was concluded that sporotrichosis in PLWH is a disease with a high prevalence in Brazil and may be associated with systemic clinical manifestations requiring longer periods of systemic antifungal therapy.<\/jats:p>","DOI":"10.1111\/myc.13627","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T07:35:54Z","timestamp":1687937754000},"page":"845-853","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Sporotrichosis co\u2010infection with human immunodeficiency virus\/acquired immunodeficiency syndrome"],"prefix":"10.1111","volume":"66","author":[{"given":"Eduardo Vinicius Grego","family":"Uemura","sequence":"first","affiliation":[{"name":"Faculdade de Ci\u00eancias da Sa\u00fade Universidade Federal da Grande Dourados  Dourados 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