{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:28:59Z","timestamp":1787167739230,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sporotrichosis caused by\n                    <jats:italic>Sporothrix brasiliensis<\/jats:italic>\n                    is a global emergent infectious disease. Due to the scarcity of therapeutic options for fungal diseases, new antifungals are urgently needed. Nikkomycin Z (NikZ) is a future option as an agent against dimorphic fungi. We evaluated NikZ monotherapy and in combination with itraconazole (ITZ; the conventional therapy) in the treatment of experimental sporotrichosis caused by\n                    <jats:italic>S.\u2009brasiliensis<\/jats:italic>\n                    in a murine model. Animals were subcutaneously infected, and treated orally for 30\u2009days. The study groups were as follows control (untreated), ITZ group (50\u2009mg\/kg\/day), and three groups treated with NikZ, two by monotherapy (200 or 400\u2009mg\/kg\/day), and one combining NikZ (400\u2009mg\/kg\/day) and ITZ. Efficacy of treatments was evaluated via body weight gain, mortality and fungal burden in tissues. Efficacy was noted in all treatment groups, and the group receiving the drug combination showed even better results than those with monotherapy. Our study shows for the first time the high potential of NikZ to be used in the treatment of sporotrichosis caused by\n                    <jats:italic>S.\u2009brasiliensis<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/myc.13629","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T02:14:57Z","timestamp":1689128097000},"page":"898-905","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Nikkomycin Z for the treatment of experimental sporotrichosis caused by\n                    <i>Sporothrix brasiliensis<\/i>"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7121-3861","authenticated-orcid":false,"given":"Vanice Rodrigues","family":"Poester","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Faculdade de Medicina (FAMED) Universidade Federal do Rio Grande (FURG) Rio Grande Brazil"},{"name":"Mycology Laboratory of FAMED\u2010FURG Rio Grande Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3538-5006","authenticated-orcid":false,"given":"L\u00edvia Silveira","family":"Munhoz","sequence":"additional","affiliation":[{"name":"Mycology Laboratory of FAMED\u2010FURG Rio Grande Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Stevens","sequence":"additional","affiliation":[{"name":"California Institute for Medical Research San Jose California USA"},{"name":"Division of Infectious Diseases and Geographic Medicine Stanford University Medical School Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6655-8715","authenticated-orcid":false,"given":"Aryse Martins","family":"Melo","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases National Institute of Health Doutor Ricardo Joge Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1407-8135","authenticated-orcid":false,"given":"Mariana Rodrigues","family":"Tr\u00e1paga","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Faculdade de Medicina (FAMED) Universidade Federal do Rio Grande (FURG) Rio Grande Brazil"},{"name":"Mycology Laboratory of FAMED\u2010FURG Rio Grande Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Martins","family":"Flores","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria (UFSM) Santa Maria Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Larwood","sequence":"additional","affiliation":[{"name":"California Institute for Medical Research San Jose California USA"},{"name":"Valley Fever Solutions Tucson Arizona 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