{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T18:29:52Z","timestamp":1773858592473,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Scedosporiosis\/lomentosporiosis is a globally emerging and crucial fungal infection. However, clinical data on <jats:italic>Scedosporium<\/jats:italic>\/<jats:italic>Lomentospora<\/jats:italic> infections in Taiwan are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to explore the clinical characteristics of <jats:italic>Scedosporium<\/jats:italic>\/<jats:italic>Lomentospora<\/jats:italic>\u2010infected patients and evaluate the susceptibility of these isolates to antifungal agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinical features of <jats:italic>Scedosporium<\/jats:italic>\/<jats:italic>Lomentospora<\/jats:italic>\u2010infected patients at a tertiary teaching hospital in Northern Taiwan between 2014 and 2021 were retrospectively reviewed; isolates from these patients were identified to species level for antifungal susceptibility testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 44 patients, 27 (61.4%) had scedosporiosis\/lomentosporiosis, whereas 17 (38.6%) were colonised with <jats:italic>Scedosporium<\/jats:italic>\/<jats:italic>Lomentospora<\/jats:italic> species. <jats:italic>Scedosporium apiospermum<\/jats:italic> was the main coloniser; scedosporiosis was primarily caused by <jats:italic>S.\u2009boydii<\/jats:italic>. Trauma history, steroid and immunosuppressant use were the most common risk factors for developing these infections. Among 27 patients with scedosporiosis\/lomentosporiosis, one was lost to follow\u2010up and seven (7\/26, 26.9%) died. Most patients with <jats:italic>S.\u2009apiospermum<\/jats:italic> infection have a history of trauma, leading to cutaneous, bone and ocular infections. Pulmonary, sinus and disseminated infections and mortality were frequently reported in patients with <jats:italic>S.\u2009boydii<\/jats:italic> infection. Voriconazole's minimum inhibitory concentration was low for <jats:italic>S.\u2009boydii<\/jats:italic>, <jats:italic>S.\u2009apiospermum<\/jats:italic> and <jats:italic>S.\u2009aurantiacum<\/jats:italic>. Caspofungin, micafungin and anidulafungin were active against <jats:italic>S.\u2009boydii<\/jats:italic> and <jats:italic>S.\u2009apiospermum<\/jats:italic>. A potentially novel <jats:italic>Scedosporium<\/jats:italic> species was identified in this study, with distinct clinical manifestations and antifungal susceptibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>At our centre, <jats:italic>S.\u2009boydii<\/jats:italic> is the main causative species of scedosporiosis; voriconazole could be the first\u2010line treatment in Taiwan. Our study supports the importance of speciation, rather than only categorising these isolates into <jats:italic>S.\u2009apiospermum<\/jats:italic> species complex.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13632","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T10:29:29Z","timestamp":1689330569000},"page":"923-935","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical manifestations and susceptibility of <i>Scedosporium\/Lomentospora<\/i> infections at a tertiary medical centre in Taiwan from 2014 to 2021: A retrospective cohort study"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2015-355X","authenticated-orcid":false,"given":"Chong Kei","family":"Lao","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine Chang Gung Memorial Hospital, Linkou Medical Centre  Taoyuan 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