{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T22:29:02Z","timestamp":1772144942874,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T00:00:00Z","timestamp":1690588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Trichosporon<\/jats:italic> is an emerging yeast that causes invasive infections in immunocompromised patients experiencing prolonged hospitalisation, indwelling venous catheters and neutropenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective observational cohort study analysed invasive <jats:italic>Trichosporon<\/jats:italic> infections (ITIs) occurring between January 2005 and December 2022 at three tertiary hospitals and compared the clinical characteristics and prognostic factors of ITIs caused by <jats:italic>Trichosporon asahii<\/jats:italic> and non\u2010<jats:italic>T<\/jats:italic>. <jats:italic>asahii<\/jats:italic> spp. After evaluating 1067 clinical isolates, we identified 46 patients with proven ITIs, defined as cases in which <jats:italic>Trichosporon<\/jats:italic> was isolated from blood, cerebrospinal fluid, or sterile tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients were separated into <jats:italic>T<\/jats:italic>. <jats:italic>asahii<\/jats:italic> and non\u2010<jats:italic>T<\/jats:italic>. <jats:italic>asahii<\/jats:italic> groups containing 25 and 21 patients, respectively, all of which except one were immunocompromised. During this period, both the number of clinical isolates and patients with ITIs (mainly <jats:italic>T<\/jats:italic>. <jats:italic>asahii<\/jats:italic>) increased; whereas, cases involving non\u2010<jats:italic>T<\/jats:italic>. <jats:italic>asahii<\/jats:italic> spp. decreased. Compared with the <jats:italic>non<\/jats:italic>\u2010<jats:italic>T<\/jats:italic>. <jats:italic>asahii<\/jats:italic> group, the <jats:italic>T<\/jats:italic>. <jats:italic>asahii<\/jats:italic> group had more patients with multiple catheters (84% vs. 33%, <jats:italic>p<\/jats:italic>\u2009=\u2009.001) and those receiving renal replacement therapy (48% vs. 14%, <jats:italic>p<\/jats:italic>\u2009=\u2009.005). The all\u2010cause 28\u2010day mortality rate after ITI in the <jats:italic>T<\/jats:italic>. <jats:italic>asahii<\/jats:italic> group (44%) was significantly higher than in <jats:italic>the<\/jats:italic> non\u2010<jats:italic>T<\/jats:italic>. <jats:italic>asahii<\/jats:italic> group (10%, Log\u2010rank <jats:italic>p<\/jats:italic>\u2009=\u2009.014). The multivariate Cox regression model revealed that <jats:italic>T<\/jats:italic>. <jats:italic>asahii<\/jats:italic> (reference, non\u2010<jats:italic>T<\/jats:italic>. <jats:italic>asahii<\/jats:italic> spp.; aHR\u2009=\u20094.3; 95% CI\u2009=\u20091.2\u201315.2, <jats:italic>p<\/jats:italic>\u2009=\u2009.024) and neutropenia for 5\u2009days or more (aHR\u2009=\u20092.2, 95% CI\u2009=\u20091.5\u20133.6, <jats:italic>p<\/jats:italic>\u2009=\u2009.035) were independent factors in the 28\u2010day mortality after ITI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The proven ITIs due to <jats:italic>T<\/jats:italic>. <jats:italic>asahii<\/jats:italic> produced more unfavourable outcomes compared with ITIs caused by non\u2010<jats:italic>T<\/jats:italic>. <jats:italic>asahii<\/jats:italic> spp.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13635","type":"journal-article","created":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T08:39:55Z","timestamp":1690619995000},"page":"992-1002","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Differences of clinical characteristics and outcome in proven invasive <i>Trichosporon<\/i> infections caused by <i>asahii<\/i> and non\u2010<i>asahii<\/i> species"],"prefix":"10.1111","volume":"66","author":[{"given":"Eun Hwa","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Infectious Disease, Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Hyuk","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Gangnam Severance Hospital Yonsei University College of Medicine  Seoul Republic of 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