{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T23:24:02Z","timestamp":1779924242853,"version":"3.53.1"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Germline pathogenic variants (PVs) in the gene encoding the GATA2 transcription factor can result in profound reductions of monocytes, dendritic cells, natural killer cells and B cells.<jats:italic>GATA2<\/jats:italic>PVs are associated with an increased risk of myeloid malignancies and a predisposition to nontuberculous mycobacterial and human papillomavirus infections. Additionally, invasive fungal infections (IFIs) have been reported in individuals with<jats:italic>GATA2<\/jats:italic>PVs, even in the absence of myeloid malignancies. In this report, we present the case of a 40\u2010year\u2010old man with Emberger syndrome (<jats:italic>GATA2<\/jats:italic>mutation, recently diagnosed acute myeloid leukaemia [AML] and history of lymphedema with hearing loss) who developed Mucorales sinusitis while receiving his first course of remission induction chemotherapy. Additionally, we review the literature on all published cases of proven IFIs in patients with<jats:italic>GATA2<\/jats:italic>PVs. Clinicians should be aware that patients with<jats:italic>GATA2<\/jats:italic>PVs could be vulnerable to opportunistic IFIs, even in the absence of AML and antineoplastic therapy. Furthermore, the distinctly unusual occurrence of mucormycosis during the first course of induction chemotherapy for AML in our patient indicates that patients with germline<jats:italic>GATA2<\/jats:italic>PVs receiving induction chemotherapy for AML might be at high risk for early onset of IFIs due to aggressive, opportunistic moulds.<\/jats:p>","DOI":"10.1111\/myc.13638","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T02:58:45Z","timestamp":1691463525000},"page":"1029-1034","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Invasive mucorales sinusitis in a young patient with Emberger syndrome and newly diagnosed<scp>AML<\/scp>: A case report and literature review of invasive fungal infections in<scp>GATA2<\/scp>deficiency"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5241-3435","authenticated-orcid":false,"given":"Chia\u2010Yu","family":"Chiu","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Centre Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Centre Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Wurster","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Centre Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoheved","family":"Gerstein","sequence":"additional","affiliation":[{"name":"Department of Clinical Cancer Genetics The University of Texas MD Anderson Cancer Centre Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle E.","family":"Hammond","sequence":"additional","affiliation":[{"name":"Department of Leukaemia The University of Texas MD Anderson Cancer Centre Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly S.","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Leukaemia The University of Texas MD Anderson Cancer Centre Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"DiNardo","sequence":"additional","affiliation":[{"name":"Department of Leukaemia The University of Texas MD Anderson Cancer Centre Houston Texas 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