{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:28:02Z","timestamp":1791325682977,"version":"4.3.1"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:00:00Z","timestamp":1695513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006506","name":"Minist\u00e9rio da Sa\u00fade","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Systemic sporotrichosis occurs when organs, other than subcutaneous tissues and lymph nodes, are infected. Interestingly, systemic sporotrichosis in apparently immunocompetent individuals is increasing in Brazil, but data on clinical manifestations and risk factors are scarce. Most of the existing data on such condition relate to people living with HIV. We aimed to study the risk factors associated with systemic sporotrichosis among HIV\u2010negative and HIV\u2010positive patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective cross\u2010sectional study with 80 patients from Brazil, diagnosed between 2014 and 2021. The association between disease classification, clinical presentation and risk factors were analysed by logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 80 patients, 29 (36.3%) presented with systemic sporotrichosis. All HIV\u2010positive patients developed the systemic form, with increased mortality (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.002). Alcohol ingestion (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.009) and diabetes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.010) were associated with systemic disease. Alcohol ingestion seemed to favour pulmonary infection (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.013) and, diabetes favoured osteoarticular (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.009) and ocular involvement (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.033). The occurrence of fever (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001) and weight loss (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.006) were significantly associated with systemic sporotrichosis, while meningeal involvement (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001) increased mortality risk. Nine (11.3%) patients died from sporotrichosis. The presence of fungal structures in the mycological examination of the patients' lesions were associated with the systemic form (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.017) and death (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study points to the factors that drive systemic sporotrichosis other than HIV, such as alcohol ingestion and diabetes. Considering the high number of patients presenting severe sporotrichosis, the recognising these factors may contribute to timely diagnosis and proper treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.13656","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:20:04Z","timestamp":1695601204000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Clinical factors associated with systemic sporotrichosis in Brazil"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0035-6261","authenticated-orcid":false,"given":"Vanessa C. R.","family":"Magalh\u00e3es","sequence":"first","affiliation":[{"name":"Department of Microbiology, Institute of Biological Sciences Universidade Federal de Minas Gerais  Belo Horizonte Brazil"},{"name":"Hospital Eduardo de Menezes Funda\u00e7\u00e3o Hospitalar do Estado de Minas Gerais (FHEMIG)  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2378-8649","authenticated-orcid":false,"given":"Salene A.","family":"Colombo","sequence":"additional","affiliation":[{"name":"Department of Preventive Veterinary Medicine, School of Veterinary Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2762-3200","authenticated-orcid":false,"given":"Nalu T. A.","family":"Peres","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute of Biological Sciences Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre S.","family":"Moura","sequence":"additional","affiliation":[{"name":"Hospital Eduardo de Menezes Funda\u00e7\u00e3o Hospitalar do Estado de Minas Gerais (FHEMIG)  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C.","family":"Lyon","sequence":"additional","affiliation":[{"name":"Hospital Eduardo de Menezes Funda\u00e7\u00e3o Hospitalar do Estado de Minas Gerais (FHEMIG)  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Lyon","sequence":"additional","affiliation":[{"name":"Hospital Eduardo de Menezes Funda\u00e7\u00e3o Hospitalar do Estado de Minas Gerais (FHEMIG)  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria R. 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