{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:38:39Z","timestamp":1778801919382,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T00:00:00Z","timestamp":1699142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p><jats:italic>H.\u2009capsulatum<\/jats:italic> is endemic in Indonesia, but the value of <jats:italic>Histoplasma<\/jats:italic> antigen detection has not been studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p><jats:italic>Histoplasma<\/jats:italic> galactomannan (GM) ELISA was applied to sera of patients with unproven pulmonary tuberculosis (TB) and patients with a positive <jats:italic>Aspergillus<\/jats:italic> GM. Both <jats:italic>Histoplasma<\/jats:italic> and <jats:italic>Aspergillus<\/jats:italic> GM tests were performed to determine any possible cross\u2010reaction with certain foods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fourteen of 122 (11.5%) sera of patients with newly diagnosed clinical TB were positive for <jats:italic>Histoplasma<\/jats:italic> GM. The positivity rate in the serum of patients 5\u20136 and 12\u2009months after TB diagnosis was 3.8% and 3.5%, respectively. Of 88 positive <jats:italic>Aspergillus<\/jats:italic> GM sera, 63 (71.6%) were also positive for <jats:italic>Histoplasma<\/jats:italic> GM. All tested foods were positive for <jats:italic>Aspergillus<\/jats:italic> GM, while 65% of foods were positive for <jats:italic>Histoplasma<\/jats:italic> GM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Galactomannan is widespread in sera and food in Jakarta, possibly related to food consumption. <jats:italic>Histoplasma<\/jats:italic> and <jats:italic>Aspergillus<\/jats:italic> antigen detection for the diagnosis will require additional means of confirming the diagnosis; negative tests may be more helpful for ruling out invasive histoplasmosis and aspergillosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13670","type":"journal-article","created":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T05:58:22Z","timestamp":1698472702000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>Histoplasma<\/i> antigen detection in unconfirmed pulmonary tuberculosis and cross\u2010reactivity 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