{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T13:05:33Z","timestamp":1787231133930,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073454"],"award-info":[{"award-number":["82073454"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["20210204190YY"],"award-info":[{"award-number":["20210204190YY"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["20220508083RC"],"award-info":[{"award-number":["20220508083RC"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hyperthermia is a common monotherapy for sporotrichosis, but only in patients with special conditions, such as pregnancy and nursing. However, hyperthermia has not been used more widely for sporotrichosis in clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>An HIV\u2010positive adult male with lymphocutaneous sporotrichosis caused by <jats:italic>Sporothrix globosa<\/jats:italic> that did not respond to conventional itraconazole therapy lasting &gt;2\u2009months received adjunctive therapy with local hyperthermia. To simulate the effects of heat exposure on the growth and morphology of <jats:italic>Sporothrix<\/jats:italic> spp. in\u00a0vitro, <jats:italic>S. globosa<\/jats:italic>, <jats:italic>S. schenckii<\/jats:italic> and <jats:italic>S. brasiliensis<\/jats:italic> were exposed to intermittent heat (42\u00b0C) for 1\u2009h a day for 7 or 28\u2009days and observed under transmission electron microscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Itraconazole combined with local hyperthermia significantly improved the lesions, and the patient was successfully cured of sporotrichosis, with no recurrence after 2\u2009years of follow\u2010up. Cultures of <jats:italic>Sporothrix<\/jats:italic> spp. treated with 7\u2009days of daily heat exposure in\u00a0vitro showed obvious decreases in colony diameters, but not numbers, compared with untreated cultures (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). After 28\u2009days of heat exposure in\u00a0vitro, <jats:italic>Sporothrix<\/jats:italic> spp. were unable to thrive (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), and ultrastructural alterations, including loose cell wall structure, incomplete cell membrane, disrupted vacuoles and fragmented nuclei, were noticeable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our case findings and in\u00a0vitro experiments on <jats:italic>Sporothrix<\/jats:italic> spp., together with a literature review of previous sporotrichosis cases, suggest that hyperthermia has a clinical role as a treatment adjunct. Large\u2010scale clinical trials are required to examine the utility of hyperthermia in various forms of cutaneous sporotrichosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13671","type":"journal-article","created":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T06:00:30Z","timestamp":1698472830000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hyperthermia is a promising potential adjunct to treating sporotrichosis: A refractory case of HIV sporotrichosis and in\u00a0vitro experiments on <i>Sporothrix<\/i> spp."],"prefix":"10.1111","volume":"67","author":[{"given":"Yuan\u2010yuan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venerology First Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology First Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng\u2010qi","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology First Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Instrument Center, State Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui\u2010li","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Zhuhai People's Hospital  Zhuhai 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