{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:16:51Z","timestamp":1787015811994,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Trichophyton rubrum<\/jats:italic>\n                      and\n                      <jats:italic>Trichophyton mentagrophytes<\/jats:italic>\n                      variant\n                      <jats:italic>interdigitalis<\/jats:italic>\n                      are the most frequent etiologic agents of onychomycosis. Diagnosis of certainty requires mycological examination, which often results unfeasible.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of our study is to describe pathogen specific dermoscopic features, allowing a differential diagnosis without the need for cultural examination, in order to prescribe the most appropriate treatment anyway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>\n                      We conducted an observational retrospective study on 54 patients with a culture proven diagnosis of distal subungual onychomycosis of the toenail, caused by\n                      <jats:italic>Trichophyton rubrum<\/jats:italic>\n                      or\n                      <jats:italic>Trichophyton mentagrophytes<\/jats:italic>\n                      variant\n                      <jats:italic>interdigitalis<\/jats:italic>\n                      . Using a videodermatoscope we collected data on nail colour (white, yellow, orange, brown, dark) and on dermoscopic patterns (aurora, spikes, jagged, ruin, linear edge, dots, striae).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010four patients, with a total of 72 nails, were eligible for this study. Analysing the association between discoloration of the nail plate and type of infection (\n                      <jats:italic>T. rubrum<\/jats:italic>\n                      or\n                      <jats:italic>T. interdigitalis<\/jats:italic>\n                      ), no correlation turned out to be statistically significant. Instead, significant associations between spikes and\n                      <jats:italic>T. rubrum<\/jats:italic>\n                      infection and striae and infection from\n                      <jats:italic>T. interdigitalis<\/jats:italic>\n                      were identified. Finally, a 100% specificity was identified for white colour and ruin pattern for\n                      <jats:italic>T. rubrum<\/jats:italic>\n                      infection, and brown colour, jagged border and aurora pattern for\n                      <jats:italic>T. interdigitalis<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Trying to find relationships between specific pathogens and dermoscopic patterns, we found out an association between spikes and striae and\n                      <jats:italic>T. rubrum<\/jats:italic>\n                      and\n                      <jats:italic>T. interdigitalis<\/jats:italic>\n                      respectively. Further larger studies are however necessary to evaluate our preliminary findings.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.13673","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T16:23:12Z","timestamp":1700065392000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Onychoscopic characteristics of\n                    <i>Trichophyton rubrum<\/i>\n                    and\n                    <i>Trichophyton interdigitalis<\/i>\n                    fungal infections: A multicentric study"],"prefix":"10.1111","volume":"67","author":[{"given":"Michela","family":"Starace","sequence":"first","affiliation":[{"name":"Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"},{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum, University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5824-214X","authenticated-orcid":false,"given":"Elisa","family":"Milan","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medicine University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Summa","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum, University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora Maria","family":"Alessandrini","sequence":"additional","affiliation":[{"name":"Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Sechi","sequence":"additional","affiliation":[{"name":"Dermatology Unit San Bortolo Hospital  Vicenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Iorizzo","sequence":"additional","affiliation":[{"name":"Private Dermatology Practice  Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilton Gioia","family":"Di\u00a0Chiacchio","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina do ABC Hospital do Servidor P\u00fablico Municipal de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilton","family":"Di\u00a0Chiacchio","sequence":"additional","affiliation":[{"name":"Head of Dermatology Clinic \u2013 Hospital do Servidor P\u00fablico Municipal de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Maria","family":"Piraccini","sequence":"additional","affiliation":[{"name":"Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"},{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum, University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16394"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12496"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1872213X13666191026090713"},{"key":"e_1_2_9_5_1","first-page":"371","article-title":"Global onychomycosis survey group. Current issues in global onychomycosis management","volume":"21","author":"Gupta AK","year":"2022","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_9_6_1","first-page":"4","article-title":"Diagnosi e Trattamento Delle Onicomicosi","volume":"3","author":"Papini M","year":"2001","journal-title":"Ottobre"},{"key":"e_1_2_9_7_1","unstructured":"Micosi superficiali \u2013 Linee guida e raccomandazioni SIDeMaST [Internet].2023.https:\/\/www.researchgate.net\/publication\/291957711_Micosi_superficiali_\u2010_Linee_guida_e_raccomandazioni_SIDeMaST"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14706"},{"issue":"1","key":"e_1_2_9_9_1","first-page":"11","article-title":"Onychoscopy: a quick and effective tool for diagnosing onychomycosis in a resource\u2010poor setting","volume":"30","author":"Hazarika N","year":"2021","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_475_19"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15358"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13237"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.1048913"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mjafi.2021.03.019"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijdvl.IJDVL_100_19"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04323.x"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13673","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T03:53:37Z","timestamp":1707278017000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.13673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,15]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/myc.13673"],"URL":"https:\/\/doi.org\/10.1111\/myc.13673","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,15]]},"assertion":[{"value":"2023-07-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13673"}}