{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T20:23:57Z","timestamp":1778963037530,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The efficacy and side effects of voriconazole plus 5\u2010flucytosine (Vori\u2009+\u20095\u2010FC) versus amphotericin B deoxycholate plus 5\u2010flucytosine (AmBd\u2009+\u20095\u2010FC) as an induction treatment for cryptococcal meningitis are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010seven patients treated with Vori\u2009+\u20095\u2010FC and 92 patients treated with AmBd\u2009+\u20095\u2010FC were included in the current study after propensity score matching (PSM) at a ratio of 1:2. Two\u2010week laboratory test results and 90\u2010day mortality were compared between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 2\u2009weeks of induction treatment, the CSF <jats:italic>Cryptococcus<\/jats:italic> sterile culture rate was 57.1% in the Vori\u2009+\u20095\u2010FC group and 76.5% in the AmBd\u2009+\u20095\u2010FC group (<jats:italic>p<\/jats:italic>\u2009=\u2009.026). No difference was found in the normalization of CSF indicators (glucose, total protein, intracranial pressure and India ink sterile rate) between the two groups. Both the Vori\u2009+\u20095FC regimen and AmBd\u2009+\u20095\u2010FC regimen obviously decreased haemoglobin concentrations, platelet counts and serum potassium levels (all <jats:italic>p<\/jats:italic>\u2009\u2264\u2009.010). Notably, the Vori\u2009+\u20095FC regimen did not influence serum creatinine levels (<jats:italic>p<\/jats:italic>\u2009=\u2009.263), while AmBd\u2009+\u20095FC increased serum creatinine levels (<jats:italic>p<\/jats:italic>\u2009=\u2009.019) after 2\u2010week induction treatment. The Vori\u2009+\u20095\u2010FC group and AmBd\u2009+\u20095\u2010FC group had similar 90\u2010day cumulative survival rates (89.9% vs. 87.8%, <jats:italic>p<\/jats:italic>\u2009=\u2009.926).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The Vori\u2009+\u20095\u2010FC regimen was associated with low 2\u2010week CSF sterile culture and was not superior to AmBd\u2009+\u20095\u2010FC as induction therapy in terms of the 90\u2010day cumulative survival rate of CM patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13674","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T18:28:40Z","timestamp":1700677720000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Voriconazole plus flucytosine is not superior to amphotericin B deoxycholate plus flucytosine as an induction regimen for cryptococcal meningitis treatment"],"prefix":"10.1111","volume":"67","author":[{"given":"Handan","family":"Zhao","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine Zhejiang University  Hangzhou China"},{"name":"The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine Zhejiang University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanqiu","family":"Lu","sequence":"additional","affiliation":[{"name":"Chongqing Public Health Medical Center Southwest University Public Health Hospital  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Ninth Hospital of Nanchang  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangying","family":"Qin","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine Zhejiang University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miaomiao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, The Second Hospital of Nanjing Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Wenzhou Central Hospital  Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongxing","family":"Yang","sequence":"additional","affiliation":[{"name":"Xixi Hospital of Hangzhou, College of Medicine Zhejiang University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Ninth Hospital of Nanchang  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guochun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Third Peoples' Hospital of Changzhou  Changzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feifei","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Wenzhou Central Hospital  Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiliang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, The Second Hospital of Nanjing Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7352-2086","authenticated-orcid":false,"given":"Lijun","family":"Xu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine Zhejiang University  Hangzhou China"},{"name":"The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine Zhejiang University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.167"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S38850"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/649858"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1710922"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16301-0"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200645070-00002"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12603"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/09564624221127356"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2012.08.009"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00029330-200802010-00024"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1L607"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2009.04.012"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myy154"},{"issue":"5","key":"e_1_2_10_15_1","first-page":"317","article-title":"Expert consensus on the diagnosis and treatment of cryptococcal meningitis","volume":"57","author":"Liu ZY","year":"2018","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.5582\/ddt.2016.01054"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13543"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2015.10.006"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13261"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2011.12.005"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2020.0001"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-022-01757-5"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe2201150"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:MYCO.0000041904.71381.e3"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00046-13"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200464180-00001"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-019-01127-8"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm123"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-010-9375-5"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110404"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/23744235.2015.1044260"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1086\/427222"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1086\/313603"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofv157"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13467"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof9010046"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/23744235.2018.1523553"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13674","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T08:53:39Z","timestamp":1707296019000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.13674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,20]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/myc.13674"],"URL":"https:\/\/doi.org\/10.1111\/myc.13674","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,20]]},"assertion":[{"value":"2023-08-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13674"}}