{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:23:07Z","timestamp":1790893387549,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The present epidemic of dermatophytosis in India is marked by an increase in chronic, recurrent and disseminated cases. A combination of oral itraconazole and topical luliconazole is being increasingly utilised by dermatologists in India. The superiority of this combination is not supported by robust clinical trial data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We conducted this randomised, open\u2010label, two arms, parallel assignment intervention trial between November 2022 and May 2023 to determine the superiority of topical 1% Luliconazole over bland emollient as adjuvant to systemic Itraconazole therapy in the management of dermatophytosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In this study, 135 patients of either sex were randomised to two study cohorts. Major exclusions being concomitant medical illness, use of concomitant medication and substance abuse. Participants were randomly assigned to receive topical bland emollient, (Cohort I, <jats:italic>n<\/jats:italic>\u2009=\u200967) or topical luliconazole, (Cohort II, <jats:italic>n<\/jats:italic>\u2009=\u200968). Both cohorts received oral itraconazole 200\u2009mg\/day (100\u2009mg BID) and levocetirizine 5\u2009mg twice a day as a systemic regime. Clinical and mycological cure at the end of 6\u2009weeks and clinical relapse among cure patients during 10\u2010week follow\u2010up were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cure rates for Cohorts I and II at 6\u2009weeks were 50 (74.62%) and 56 (82.35%), (<jats:italic>p<\/jats:italic>\u2009=\u2009.46), respectively. During the 4\u2010week follow\u2010up period, clinical relapses were observed in 16 (32%) of the 50 patients in Cohort I and 12 (21.43%) of the 56 patients in Cohort II (<jats:italic>p<\/jats:italic>\u2009=\u2009.18). Luliconazole cohort shows a significantly higher medical cost (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study shows a similar cure rate and relapse rate for patients receiving topical Luliconazole versus topical bland emollient as an adjuvant to the systemic itraconazole regime.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13681","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:59:10Z","timestamp":1702601950000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of the benefit of the addition of 1% topical luliconazole versus topical bland emollient to the systemic itraconazole therapy for the management of disseminated dermatophytosis: A randomised control trial"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5931-8026","authenticated-orcid":false,"given":"Deval K.","family":"Rana","sequence":"first","affiliation":[{"name":"Department of Pharmacology L.M. College of Pharmacy  Ahmedabad Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3452-9696","authenticated-orcid":false,"given":"Tithi S.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pharmacology L.M. College of Pharmacy  Ahmedabad Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8775-9566","authenticated-orcid":false,"given":"Mansi H.","family":"Rohit","sequence":"additional","affiliation":[{"name":"Department of Pharmacology L.M. College of Pharmacy  Ahmedabad Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5578-2335","authenticated-orcid":false,"given":"Nayankumar H.","family":"Patel","sequence":"additional","affiliation":[{"name":"GCS Medical College Hospital and Research Centre  Ahmedabad Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9914-8539","authenticated-orcid":false,"given":"Avinash D.","family":"Khadela","sequence":"additional","affiliation":[{"name":"Department of Pharmacology L.M. College of Pharmacy  Ahmedabad Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6834-0755","authenticated-orcid":false,"given":"Yaksh P.","family":"Oza","sequence":"additional","affiliation":[{"name":"GCS Medical College Hospital and Research Centre  Ahmedabad Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2331-3598","authenticated-orcid":false,"given":"Jigna K.","family":"Padhiyar","sequence":"additional","affiliation":[{"name":"GCS Medical College Hospital and Research Centre  Ahmedabad Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.15570\/ACTAAPA.2022.23"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.4269\/AJTMH.21-1022"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2021.1942421"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S3690"},{"key":"e_1_2_12_6_1","first-page":"2581","article-title":"Terbinafine preferred antifungal with a focus on dermatophytes (a review)","volume":"3","author":"Panday M","year":"2020","journal-title":"Acta Sci Microbiol"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8598.123442"},{"key":"e_1_2_12_8_1","doi-asserted-by":"crossref","unstructured":"SinghS AnchanVN ChandraU RahejaR.Multidrug therapy with terbinafine and itraconazole is not superior to itraconazole alone in current epidemic of altered dermatophytosis in India: a randomized pragmatic. doi:10.1101\/19003947","DOI":"10.1101\/19003947"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(88)70037-7"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S389697"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12895-018-0073-1\/TABLES\/3"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11046-008-9109-0"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2021.1941868"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02706-13"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00321-21"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.idoj_643_22"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/MYC.13560"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/IJD.IJD_548_19"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMADERMATOL.2022.3745"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.25259\/IJDVL_1025_19"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01964-19"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/MYC.13367"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/CE.S49629"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13681","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T08:53:08Z","timestamp":1707295988000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.13681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,14]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/myc.13681"],"URL":"https:\/\/doi.org\/10.1111\/myc.13681","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,14]]},"assertion":[{"value":"2023-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13681"}}