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The immune response related to skin cells is complex and its understanding is essential to the comprehension of each cell's role and the discovery of treatment alternatives. The first studies of trained immunity (TI) described the ability of monocytes, macrophages and natural killer (NK) cells to develop a memory\u2010like response. However, the duration of TI does not reflect the shorter lifespan of these cells. These conclusions supported later studies showing that TI can be observed in stem and haematopoietic cells and, more recently, also in non\u2010immune skin cells such as fibroblasts, highlighting the importance of resident cells in response to skin disorders. Besides, the participation of less studied proinflammatory cytokines in the skin immune response, such as IL\u201036\u03b3, shed light into a new possibility of inflammatory pathway blockade by drugs. In this review, we will discuss the skin immune response associated with fungal infections, the role of TI in skin and clinical evidence supporting opportunities and challenges of TI and other inflammatory responses in the pathogenesis of fungal skin infections.<\/jats:p>","DOI":"10.1111\/myc.13682","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T00:44:31Z","timestamp":1705884271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Skin innate immune response against fungal infections and the potential role of trained immunity"],"prefix":"10.1111","volume":"67","author":[{"given":"Amanda","family":"Bombassaro","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases Canisius\u2010Wilhelmina Hospital  Nijmegen The Netherlands"},{"name":"Program in Microbiology, Parasitology and Pathology, Biological Sciences, Department of Basic Pathology Federal University of Paran\u00e1  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Marcondes","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos P.","family":"Taborda","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Department of Dermatology, LIM53, Institute of Tropical Medicine University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo A. 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