{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T15:11:37Z","timestamp":1789225897437,"version":"build-2803163510"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Candida<\/jats:italic> species are now considered global threats by the CDC and WHO. <jats:italic>Candida auris<\/jats:italic> specifically is on the critical pathogen threat list along with <jats:italic>Candida albicans<\/jats:italic>. In addition, it is not uncommon to find <jats:italic>Candida<\/jats:italic> spp. in a mixed culture with bacterial organisms, especially <jats:italic>Staphylococcus aureus<\/jats:italic> producing polymicrobial infections. To eradicate these organisms from the environment and from patient surfaces, surface agents such as chlorhexidine (CHD) and Puracyn are used. Biofilm disrupters (BDs) are novel agents with a broad spectrum of antimicrobial activity and have been used in the management of chronic wounds and to sterilise environmental surfaces for the past several years. The goal of this study was to evaluate BDs (BlastX, Torrent, NSSD) and CHD against <jats:italic>Candida<\/jats:italic> spp. and <jats:italic>S. aureus<\/jats:italic> using zone of inhibition assays, biofilm and time\u2010kill assays. All BDs and CHD inhibited <jats:italic>C. auris<\/jats:italic> growth effectively in a concentration\u2010dependent manner. Additionally, CHD and the BDs showed excellent antimicrobial activity within polymicrobial biofilms. A comparative analysis of the BDs and CHD against <jats:italic>C. auris and C. albicans<\/jats:italic> using biofilm kill\u2010curves showed at least 99.999% killing. All three BDs and CHD have excellent activity against different <jats:italic>Candida<\/jats:italic> species, including <jats:italic>C. auris<\/jats:italic>. However, one isolate of <jats:italic>C. auris<\/jats:italic> in a polymicrobial biofilm assay showed resistance\/tolerance to CHD, but not to the BDs. The fungicidal activity of these novel agents will be valuable in eradicating surface colonisation of <jats:italic>Candida spp<\/jats:italic>, especially <jats:italic>C. auris<\/jats:italic> from colonised environmental surfaces and from wounds in colonised patients.<\/jats:p>","DOI":"10.1111\/myc.13684","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T04:05:37Z","timestamp":1703217937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy of biofilm disrupters against <i>Candida auris<\/i> and other <i>Candida<\/i> species in monomicrobial and polymicrobial biofilms"],"prefix":"10.1111","volume":"67","author":[{"given":"Claudia A.","family":"Cox","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Medical College of Georgia at Augusta University  Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias 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