{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:40:38Z","timestamp":1791265238698,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The clinical features of central nervous system (CNS) sporotrichosis are derived from case reports and a limited series of cases. Our objective was to carry out a systematic review and meta\u2010analysis of CNS sporotrichosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We searched PubMed\/MEDLINE, Embase, Scopus, and LILACS on 9 September 2023. Our inclusion criteria were documentation of\n                      <jats:italic>Sporothrix<\/jats:italic>\n                      and demonstrated CNS involvement. A metaproportion or metamean analysis was performed to estimate a summary proportion with 95% confidence intervals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 52 cases of CNS sporotrichosis published from 1966 to 2023. Forty\u2010six patients were male (88%, 95% CI: 77\u201395), and the mean age was 39\u2009years (95% CI: 36\u201343). Close contact with cats was reported in 55% of cases (95% CI: 37\u201372). Thirty\u2010two (61.5%) patients were from Brazil, 18 patients from the United State of America (34.6%). Only two\n                      <jats:italic>Sporothrix<\/jats:italic>\n                      species were reported:\n                      <jats:italic>S. schenckii<\/jats:italic>\n                      (26\/41, 63%), and\n                      <jats:italic>S. brasiliensis<\/jats:italic>\n                      (15\/41, 37%). The most common neurological symptom was headache. Meningitis was chronic in approximately 80% of cases. A significant majority of the patients were immunocompromised. HIV infection was the primary cause of immunosuppression (85%, 95% CI: 61\u201395). Overall mortality was 56% (22\/39). The comparison of Kaplan\u2013Meier survival curve showed a higher mortality with a statistically significant difference in immunosuppressed patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.019).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CNS sporotrichosis represents a notable cause of chronic meningitis, especially in individuals living in the Americas with HIV infection and concurrent skin lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.13697","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T22:05:57Z","timestamp":1708380357000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinical characteristics, diagnosis, and treatment of central nervous system sporotrichosis: Systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2097-389X","authenticated-orcid":false,"given":"V\u00edtor Falc\u00e3o","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Department of Infectious and Parasitic Diseases Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia Figueiredo","family":"Petrucci","sequence":"additional","affiliation":[{"name":"Department of Infectious and Parasitic Diseases Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariane","family":"Taborda","sequence":"additional","affiliation":[{"name":"Department of Infectious and Parasitic Diseases Hospital das Cl\u00ednicas da Faculdade de Medicina da 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