{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:15:49Z","timestamp":1787015749288,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post\u2010tuberculosis lung abnormality (PTLA) is the most common risk factor for developing chronic pulmonary aspergillosis (CPA). However, the prevalence and incidence of CPA in PTLA patients in India remain unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to ascertain the incidence and prevalence of CPA in subjects with PTLA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We identified a cohort of pulmonary tuberculosis who completed anti\u2010tuberculosis therapy (ATT) before November 2019 from the records of the 12 tuberculosis treatment centers attached to the national program. We recorded the clinical and demographic details. We performed computed tomography (CT) of the chest and estimated serum\n                      <jats:italic>A. fumigatus<\/jats:italic>\n                      \u2010specific IgG. We categorised subjects as PTLA with or without CPA using a composite of clinical, radiological, and microbiological features. We resurveyed the subjects at 6\u2009months (or earlier) for the presence of new symptoms. We calculated the prevalence and the incidence rate (per 100\u2010person years) of CPA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 117 subjects with PTLA, with a median of 3\u2009years after ATT completion. Eleven subjects had CPA in the initial survey, and one additional case developed CPA during the second survey. The prevalence of CPA in PTLA subjects was 10.3% (12\/117). The total observation period was 286.7 person\u2010years. The median (interquartile range) time to develop CPA after ATT completion was 12.5 (5\u201336.7) months. We found the CPA incidence rate (95% confidence interval) of 4.2 (1.8\u20136.5) per 100\u2010person years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Chronic pulmonary aspergillosis complicates 10% of PTLA subjects after successful outcomes with ATT. Four new CPA cases may develop per 100\u2010persons years of observation after ATT completion. We suggest screening patients with PTLA who develop new symptoms for CPA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.13711","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T02:04:09Z","timestamp":1709085849000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Incidence and prevalence of chronic pulmonary aspergillosis in patients with post\u2010tuberculosis lung abnormality: Results from a community survey in North India"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4839-0138","authenticated-orcid":false,"given":"Kathirvel","family":"Soundappan","sequence":"first","affiliation":[{"name":"Department of Community Medicine and School of Public Health Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6505-6019","authenticated-orcid":false,"given":"Inderpaul Singh","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine PGIMER  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Prabhakar","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samriti","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine PGIMER  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Raju","sequence":"additional","affiliation":[{"name":"Civil Hospital  Panchkula Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahajal","family":"Dhooria","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine PGIMER  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuruswamy Thurai","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine PGIMER  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0410-8468","authenticated-orcid":false,"given":"Valliappan","family":"Muthu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine PGIMER  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9097-9253","authenticated-orcid":false,"given":"Shivaprakash M.","family":"Rudramurthy","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunaloke","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Doodhadhari Burfani Hospital  Haridwar Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4714-6299","authenticated-orcid":false,"given":"Mandeep","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2547-7668","authenticated-orcid":false,"given":"Ritesh","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine PGIMER  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Global Tuberculosis Report 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treatment response in chronic pulmonary aspergillosis: role of clinical, spirometric and immunological markers","volume":"25","author":"Sehgal IS","year":"2019","journal-title":"Clin Microbiol 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