{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T21:45:11Z","timestamp":1768081511488,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Invasive pulmonary aspergillosis (IPA) is a relatively common infection in patients with acute myeloid leukaemia (AML), and is associated with high mortality rates. Optimising early detection is key to reduce the burden of IPA in this population. In this retrospective cohort study, we evaluated the added value of baseline chest CT before start of classical induction chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult patients receiving first\u2010line intensive chemotherapy for AML were included if a baseline chest CT scan was available (\u00b17\u2009days). Data were collected from the electronic health record. IPA was classified using the EORTC\/MSGERC 2020 consensus definitions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 2015 and 2019, 99 patients were included. During first\u2010line treatment, 29\/99 (30%) patients developed a probable IPA. Baseline chest CT was abnormal in 61\/99 (62%) and 14\/61 (23%) patients had typical radiological signs for IPA. An abnormal scan showed a trend towards higher risk for IPA (hazard ratio (HR): 2.12; 95% CI 0.95\u20134.84). Ground glass opacities were a strong predictor for developing IPA (HR 3.35: 95% CI 1.61\u20137.00). No probable\/proven IPA was diagnosed at baseline; however, a bronchoalveolar lavage (BAL) at baseline was only performed in seven patients. Twelve\u2010week mortality was higher in patients with IPA (7\/26, 27% vs. 5\/59, 8%; <jats:italic>p<\/jats:italic>\u2009=\u2009.024).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Baseline chest CT scan could be an asset in the early diagnosis of IPA and contribute to risk estimation for IPA. In patients with an abnormal baseline CT, performing a BAL should be considered more frequently, and not only in patients with radiological findings typical for IPA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13715","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T10:50:18Z","timestamp":1710327018000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Baseline chest computed tomography for diagnosis of invasive aspergillosis in patients with acute myeloid leukaemia treated with intensive chemotherapy: A retrospective single\u2010centre cohort study"],"prefix":"10.1111","volume":"67","author":[{"given":"Emilie","family":"Janssens","sequence":"first","affiliation":[{"name":"Department of Hematology Ghent University Hospital  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9418-8256","authenticated-orcid":false,"given":"Sammy","family":"Huygens","sequence":"additional","affiliation":[{"name":"Department of Hematology Ghent University Hospital  Ghent Belgium"},{"name":"Department of Internal Medicine, Section of Infectious Diseases and Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ine","family":"Moors","sequence":"additional","affiliation":[{"name":"Department of Hematology Ghent University Hospital  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke","family":"Delie","sequence":"additional","affiliation":[{"name":"Department of Hematology Ghent University Hospital  Ghent 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Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerina","family":"Boelens","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Ghent University Hospital  Ghent Belgium"},{"name":"Department of Diagnostic Sciences Ghent University  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lieve","family":"Morb\u00e9e","sequence":"additional","affiliation":[{"name":"Department of Radiology Ghent University Hospital  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Schauwvlieghe","sequence":"additional","affiliation":[{"name":"Department of Hematology Ghent University Hospital  Ghent Belgium"},{"name":"Department of Hematology AZ Sint\u2010Jan  Bruges 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