{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:59:03Z","timestamp":1789095543788,"version":"build-2803163510"},"reference-count":58,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Candidaemia is a life\u2010threatening disease that is associated with high mortality, especially in intensive care units (ICUs). The number of comprehensive studies dealing with the epidemiologic characteristics of biofilm\u2010related properties is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study evaluated the clinical characteristics of candidaemia, to assess the biofilm\u2010forming properties of isolates, and to identify the risk factors of mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>A total of 149 candidaemia episodes from the University of Debrecen, Clinical Centre, between January 2020 and December 2023 were investigated retrospectively. The susceptibility of <jats:italic>Candida<\/jats:italic> isolates to fluconazole, amphotericin B, anidulafungin, caspofungin, and micafungin was evaluated and compared to the susceptibility of 1\u2010day\u2010old biofilms. Multivariate logistic regression analysis was applied to identify the independent predictors of 30\u2010day mortality rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most common <jats:italic>Candida<\/jats:italic> species was <jats:italic>Candida albicans<\/jats:italic> (41%), followed by <jats:italic>C<\/jats:italic>. <jats:italic>parapsilosis<\/jats:italic> (20%), <jats:italic>C<\/jats:italic>. <jats:italic>glabrata<\/jats:italic> (14%), <jats:italic>C<\/jats:italic>. <jats:italic>tropicalis<\/jats:italic> (13%), rare <jats:italic>Candida<\/jats:italic> species (7%), and <jats:italic>C<\/jats:italic>. <jats:italic>krusei<\/jats:italic> (5%). Sixty\u2010six percent of <jats:italic>Candida<\/jats:italic> isolates were biofilm formers and 44% had high metabolic activity. The 30\u2010day mortality rate was 52%, which was higher in ICUs (65%). The logistic regression analysis revealed several factors significantly influencing mortality including ICU admission (odds ratio [OR] 2.99, 95% confidence interval [CI] 1.17\u20138.04, <jats:italic>p<\/jats:italic>\u2009=\u20090.025), fluconazole treatment (OR 4.12, 95% CI 1.62\u201311.42, <jats:italic>p<\/jats:italic>\u2009=\u2009.004), and pneumonia (OR 0.261, 95% CI 0.1\u20130.67, <jats:italic>p<\/jats:italic>\u2009=\u2009.006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This comprehensive analysis supports the better characterisation of candidaemia in healthcare settings, which ultimately may reduce mortality among patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13727","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T06:10:00Z","timestamp":1713852600000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Epidemiology, clinical characteristics, outcome and biofilm forming properties in candidaemia: A single\u2010centre retrospective 4\u2010year analysis from Hungary"],"prefix":"10.1111","volume":"67","author":[{"given":"Fruzsina","family":"Kov\u00e1cs","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine University of Debrecen  Debrecen Hungary"},{"name":"Doctoral School of Pharmaceutical Sciences University of Debrecen  Debrecen Hungary"},{"name":"Medical Microbiology, Clinical Centre University of Debrecen  Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9mi","family":"Balla","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine University of Debrecen  Debrecen Hungary"},{"name":"Doctoral School of Pharmaceutical Sciences University of Debrecen  Debrecen Hungary"},{"name":"Medical Microbiology, Clinical Centre University of Debrecen  Debrecen 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