{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:22:22Z","timestamp":1784035342307,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prevalence of fungal bloodstream infections (BSI), especially candidaemia, has been increasing globally during the last decades. Fungal diagnosis is still challenging due to the slow growth of fungal microorganisms and need for special expertise. Fungal polymicrobial infections further complicate the diagnosis and extend the time required. Epidemiological data are vital to generate effective empirical treatment strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The overall aim of this project is to describe the epidemiology of monomicrobial candidaemia and polymicrobial BSI, both with mixed fungaemia and with mixed <jats:italic>Candida<\/jats:italic>\/bacterial BSIs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a single\u2010centre retrospective epidemiological study that encompasses 950,161 blood cultures during the years 2010 to 2020. The epidemiology of monomicrobial and polymicrobial candidaemia episodes were investigated from the electronic records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that 1334 candidaemia episodes were identified belonging to 1144 individual patients during 2010 to 2020. <jats:italic>Candida albicans<\/jats:italic> was the most prevalent species detected in candidaemia patients, representing 57.7% of these episodes. <jats:italic>Nakaseomyces<\/jats:italic> (<jats:italic>Candida<\/jats:italic>) <jats:italic>glabrata<\/jats:italic> and <jats:italic>Candida parapsilosis complex<\/jats:italic> showed an increasing trend compared to previous studies, whereas <jats:italic>Candida albicans<\/jats:italic> demonstrated a decrease. 19.8% of these episodes were polymicrobial and 17% presented with mixed <jats:italic>Candida<\/jats:italic>\/bacterial BSIs while 2.8% were mixed fungaemia. <jats:italic>C. albicans<\/jats:italic> and <jats:italic>N. glabrata<\/jats:italic> were the most common combination (51.4%) in mixed fungaemia episodes. <jats:italic>Enterococcus<\/jats:italic> and <jats:italic>Lactobacillus<\/jats:italic> spp. were the most common bacteria isolated in mixed <jats:italic>Candida<\/jats:italic>\/bacterial BSIs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Polymicrobial growth with candidaemia is common, mostly being mixed <jats:italic>Candida<\/jats:italic>\/bacterial BSIs. <jats:italic>C. albicans<\/jats:italic> was detected in more than half of all the candidaemia patients however showed a decreasing trend in time, whereas an increase is noteworthy in <jats:italic>C. parapsilosis<\/jats:italic> complex and <jats:italic>N. glabrata<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13729","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T09:05:01Z","timestamp":1714381501000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Epidemiological patterns of candidaemia: A comprehensive analysis over a decade"],"prefix":"10.1111","volume":"67","author":[{"given":"Gordon","family":"Ferngren","sequence":"first","affiliation":[{"name":"Division of Clinical Microbiology, Department of Laboratory Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology, Department of Laboratory Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5318-2942","authenticated-orcid":false,"given":"Tugce","family":"Unalan\u2010Altintop","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology, Department of Laboratory Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Medical Microbiology Hacettepe University Medical School  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7043-9815","authenticated-orcid":false,"given":"Patrik","family":"Dinn\u00e9tz","sequence":"additional","affiliation":[{"name":"School of Natural Sciences, Technology and Environmental Studies S\u00f6dert\u00f6rn University  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volkan","family":"\u00d6zenci","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology, Department of Laboratory Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Clinical Microbiology Karolinska University Hospital  Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0b013e32833e84d2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12212"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4161\/viru.26187"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.26"},{"key":"e_1_2_8_6_1","volume-title":"WHO fungal priority pathogens list to guide research, development and public health 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