{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T20:05:51Z","timestamp":1778011551792,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T00:00:00Z","timestamp":1715040000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100015142","name":"Post-Finasteride Syndrome Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015142","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Triazole\u2010resistant <jats:italic>Aspergillus fumigatus<\/jats:italic> (TRAF) isolates are a growing public health problem with worldwide distribution. Epidemiological data on TRAF is limited in Africa, particularly in West Africa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to screen for the environmental presence of TRAF isolates in the indoor air of two hospitals in Burkina Faso.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Air samples were collected in wards housing patients at risk for invasive aspergillosis, namely infectious diseases ward, internal medicine ward, nephrology ward, pulmonology ward, medical emergency ward and paediatric ward. Sabouraud Dextrose Agar supplemented with triazoles was used to screen the suspected TRAF isolates and EUCAST method to confirm the resistance of suspected isolates. Sequencing of <jats:italic>cyp51A<\/jats:italic> gene was used to identify the resistance mechanism of confirmed TRAF isolates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 198 samples collected and analysed, 67 showed growth of <jats:italic>A. fumigatus<\/jats:italic> isolates. The prevalence of TRAF isolates was 3.23% (4\/124). One TRAF isolate exhibited a pan\u2010triazole resistance. Sequencing of <jats:italic>cyp51A<\/jats:italic> gene identified the TR34\/L98H mutation for this pan\u2010triazole resistant isolate. This study showed for the first time the circulation of the pan\u2010azole resistant isolate harbouring the TR34\/L98H mutation in Burkina Faso.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings emphasise the need to map these TRAF isolates in all parts of Burkina Faso and to establish local and national continuous surveillance of environmental and clinical TRAF isolates in this country.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13732","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T11:54:26Z","timestamp":1715082866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["First detection of triazole\u2010resistant <i>aspergillus fumigatus<\/i> harbouring the TR34\/L98H <i>Cyp51A<\/i> mutation in Burkina 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