{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T05:21:26Z","timestamp":1771737686286,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010tuberculosis lung abnormality (PTLA) is the most common risk factor for chronic pulmonary aspergillosis (CPA), and 14%\u201325% of the subjects with PTLA develop CPA. The pathogenesis and the host immune response in subjects with PTLA who develop CPA need to be better understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively compared the innate and adaptive immune responses mounted by patients of PTLA with or without CPA (controls). We studied the neutrophil oxidative burst (by dihydrorhodamine 123 test), classic (serum C3 and C4 levels) and alternative (mannose\u2010binding lectin [MBL] protein levels) complement pathway, serum immunoglobulins (IgG, IgM and IgA), B and T lymphocytes and their subsets in subjects with PTLA with or without CPA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 111 subjects (58 CPA and 53 controls) in the current study. The mean\u2009\u00b1\u2009SD age of the study population was 42.6\u2009\u00b1\u200915.7\u2009years. The cases and controls were matched for age, gender distribution and body weight. Subjects with CPA had impaired neutrophil oxidative burst, lower memory T lymphocytes and impaired Th\u20101 immune response (lower Th\u20101 lymphocytes) than controls. We found no significant difference between the two groups in the serum complement levels, MBL levels, B\u2010cell subsets and other T lymphocyte subsets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Subjects with CPA secondary to PTLA have impaired neutrophil oxidative burst and a lower Th\u20101 response than controls.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13746","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T11:54:44Z","timestamp":1716206084000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Innate and adaptive immune responses in subjects with <scp>CPA<\/scp> secondary to post\u2010pulmonary tuberculosis lung abnormalities"],"prefix":"10.1111","volume":"67","author":[{"given":"Naresh Kumar","family":"Chirumamilla","sequence":"first","affiliation":[{"name":"Department of Internal medicine Postgraduate Institute of Medical Education and 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