{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:41:04Z","timestamp":1753879264358,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Coccidioidomycosis is a systemic fungal disease endemic to arid regions of the Western Hemisphere. In the south\u2010western US, <jats:italic>Coccidioides<\/jats:italic> spp. may account for up to 20%\u201325% of all cases of community acquired pneumonia. Clinical manifestations vary widely, from asymptomatic infection to life\u2010threatening disease, especially in immunocompromised hosts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The primary objective of the study was to characterise cases of coccidioidomycosis in an area of the United States not considered traditionally endemic for the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a single\u2010centre retrospective study of all cases of coccidioidomycosis from 1 January 2000 to 31 December 2020, in the University of Oklahoma Health Sciences Medical Center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 26 patients were included for analysis. The central nervous system (CNS) and the lungs were the sites most frequently involved. Twenty (77%) had travelled to a coccidioidomycosis endemic region. Most were male (81%) with a median age of 42\u2009years (range: 3\u201378\u2009years). The majority (46%) were Caucasians, 19% were African American, 19% Hispanic, and 12% Native American. The most common comorbidities were diabetes mellitus and acquired immunodeficiency syndrome, identified in 27% and 23% of patients, respectively. Patients on immunosuppressive therapy accounted for 12% of all cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study is one of the largest single\u2010centre case series of coccidioidomycosis from a non\u2010endemic area. Diabetes mellitus was the most frequent comorbidity. Compared to other case series of coccidioidomycosis, our patient population had higher rates of immunosuppression and had both a higher rate of disseminated disease and overall mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13749","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T02:55:09Z","timestamp":1716519309000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Coccidioidomycosis in Oklahoma: A retrospective case series"],"prefix":"10.1111","volume":"67","author":[{"given":"Brian","family":"Scott","sequence":"first","affiliation":[{"name":"Department of Medicine, Section of Infectious Diseases University of Oklahoma Health Sciences Center  Oklahoma City Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Sassine","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Infectious Diseases University of Oklahoma Health Sciences Center  Oklahoma City Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Internal Medicine University of Oklahoma Health Sciences Center  Oklahoma City Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9363-6280","authenticated-orcid":false,"given":"Nelson Iv\u00e1n","family":"Agudelo\u00a0Higuita","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Infectious Diseases University of Oklahoma Health Sciences Center  Oklahoma City Oklahoma USA"},{"name":"Instituto de Enfermedades Tropicales y Parasitolog\u00eda Antonio Vidal  Tegucigalpa Honduras"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-020-00431-2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1175\/wcas-d-20-0036.1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1206.060028"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss7107a1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1029\/2019GH000209"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2010.547995"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myz111"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2509.190023"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis1028"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1154"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2302.160505"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000126762.91040.fd"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofab543"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/319203"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1998.58.309"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011025"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof9050554"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390814"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0049-0172(99)80003-1"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2017-000247"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.03.033"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12963-018-0166-4"},{"key":"e_1_2_9_24_1","unstructured":"Oklahoma Diabetes Prevention Report 2023.chrome\u2010extension:\/\/efaidnbmnnnibpcajpcglclefindmkaj\/https:\/\/oklahoma.gov\/content\/dam\/ok\/en\/health\/health2\/aem\u2010documents\/health\u2010promotion\/center\u2010for\u2010chronic\u2010disease\u2010prevention\u2010\u2010\u2010health\u2010promotion\/2023%20Oklahoma%20Diabetes%20Prevention%20Report.pdf. 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