{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T19:52:11Z","timestamp":1772913131680,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:00:00Z","timestamp":1720656000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Candida auris<\/jats:italic>, a multidrug\u2010resistant fungal pathogen, has received considerable attention owing to its recent surge, especially in South America, which coincides with the ongoing global COVID\u201019 pandemic. Understanding the clinical and microbiological characteristics of outbreaks is crucial for their effective management and control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This retrospective observational study aimed to characterize a <jats:italic>C.\u2009auris<\/jats:italic> outbreak at a Peruvian referral hospital between January 2021 and July 2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were collected from hospitalized patients with positive <jats:italic>C.\u2009auris<\/jats:italic> culture results. Microbiological data and antifungal susceptibility test results were analysed. Additionally, infection prevention and control measures have been described. Statistical analysis was used to compare the characteristics between the infected and colonized patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010three patients were identified, mostly male (66.7%), with a median age of 53\u2009years. Among them, 18 (54.5%) were colonized, and 15 (45.5%) were infected. Fungemia was the predominant presentation (80%), with notable cases of fungemia in tuberculosis patients with long\u2010stay devices for parenteral anti\u2010tuberculosis therapy. Seventy\u2010five percent of the isolates exhibited fluconazole resistance. Echinocandins were the primary treatment, preventing fungemia recurrence within 30\u2009days. Infected patients had significantly longer hospital stays than colonized patients (100 vs. 45\u2009days; <jats:italic>p<\/jats:italic>\u2009=\u2009.023). Hospital mortality rates were 46.7% and 25% in the infected and fungemia patients, respectively. Simultaneous outbreaks of multidrug\u2010resistant bacteria were documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study underscores the severity of a <jats:italic>C.\u2009auris<\/jats:italic> outbreak at a referral hospital in Peru, highlighting its significant impact on patient outcomes and healthcare resources. The high prevalence of fluconazole\u2010resistant isolates, leading to prolonged hospital stay and high mortality rates, particularly in cases of fungemia, underscores the critical need for effective infection prevention and control strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13765","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T08:06:21Z","timestamp":1720685181000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical and microbiological characteristics of a hospital outbreak of <i>Candida auris<\/i> in a referral hospital in Lima, Peru"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3823-4737","authenticated-orcid":false,"given":"Giancarlo","family":"P\u00e9rez\u2010Lazo","sequence":"first","affiliation":[{"name":"Escuela de Medicina Universidad C\u00e9sar Vallejo  Piura Peru"},{"name":"Division of Infectious Diseases 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