{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:43:33Z","timestamp":1787237013884,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T00:00:00Z","timestamp":1720915200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The radiological manifestations of central nervous system (CNS) cryptococcosis are diverse and often subtle. There is heterogeneity on how different neuroimaging patterns impact prognosis. This study aims to assess the association between the neuroimaging and clinical outcomes of CNS cryptococcosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All patients with CNS cryptococcosis between July 2017 and April 2023 who underwent brain magnetic resonance imaging (MRI) were included. The primary outcome was mortality during hospitalisation. Secondary outcomes were readmission, ventricular shunting, duration of hospitalisation and time to the first negative cerebrospinal fluid culture. We compared the outcomes for each of the five main radiological findings on the brain MRI scan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 46 proven CNS cryptococcosis cases. The two main comorbidity groups were HIV infection (20, 43%) and solid organ transplantation (10, 22%), respectively. Thirty\u2010nine patients exhibited at least one radiological abnormality (85%), with the most common being meningeal enhancement (34, 74%). The mortality rates occurred at 11% (5\/46) during hospitalisation. We found no significant disparities in mortality related to distinct radiological patterns. The presence of pseudocysts was significantly associated with the need for readmission (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.027). The ventricular shunting was significantly associated with the presence of pseudocysts (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.005) and hydrocephalus (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.044).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this study, there is no association between brain MRI findings and mortality. Larger studies are needed to evaluate this important issue.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.13767","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:20:38Z","timestamp":1721002838000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association between neuroimaging and clinical outcomes in individuals with central nervous system cryptococcosis"],"prefix":"10.1111","volume":"67","author":[{"given":"Juliana Cavadas","family":"Teixeira","sequence":"first","affiliation":[{"name":"Division of Infectious and Parasitic Diseases, Hospital das Cl\u00ednicas (HCFMUSP), Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2097-389X","authenticated-orcid":false,"given":"V\u00edtor Falc\u00e3o","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Division of Infectious and Parasitic Diseases, Hospital das Cl\u00ednicas (HCFMUSP), Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lio Rodrigues","family":"Gomes","sequence":"additional","affiliation":[{"name":"Division of Neurology, Hospital das Cl\u00ednicas (HCFMUSP), Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzana Mesquita","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Microbiology Section of Division Central Laboratory, Hospital das Cl\u00ednicas (HCFMUSP), Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelina da Motta Pacheco Alves","family":"de Araujo","sequence":"additional","affiliation":[{"name":"Microbiology Section of Division Central Laboratory, Hospital das Cl\u00ednicas (HCFMUSP), Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela Carvalho Leme Vieira","family":"da Cruz","sequence":"additional","affiliation":[{"name":"Division of Infectious and Parasitic Diseases, Hospital das Cl\u00ednicas (HCFMUSP), Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariane","family":"Taborda","sequence":"additional","affiliation":[{"name":"Division of Infectious and Parasitic Diseases, Hospital das Cl\u00ednicas (HCFMUSP), Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Satie Gon\u00e7alves Kono","family":"Magri","sequence":"additional","affiliation":[{"name":"Division of Infectious and Parasitic Diseases, Hospital das Cl\u00ednicas (HCFMUSP), Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Ernesto","family":"Vidal","sequence":"additional","affiliation":[{"name":"Division of Infectious and Parasitic Diseases, Hospital das Cl\u00ednicas (HCFMUSP), Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Department of Neurology Instituto de Infectologia Em\u00edlio Ribas  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Catharina de Seixas Santos","family":"Nastri","sequence":"additional","affiliation":[{"name":"Division of Infectious and Parasitic Diseases, Hospital das Cl\u00ednicas (HCFMUSP), Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo 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Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200205030-00009"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.3.611"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30243-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.287085135"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2014.10.007"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/0100-3984.2016.0017"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001950"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181814e76"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040021"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-017-3142-1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-020-05661-9"},{"key":"e_1_2_8_13_1","volume-title":"Prevention 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