{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:19:13Z","timestamp":1789258753227,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Invasive fungal infections (IFI), prevalent in critically ill ICU patients, have gained attention due to post\u2010COVID\u201019 epidemiological shifts. Notably, COVID\u201019\u2010associated aspergillosis and candidiasis pose significant risks. WHO recognises key fungal pathogens, emphasising the need for enhanced research and interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The CHARTER\u2010IFI study retrospectively examines 186,310 individuals admitted to ICUs in Italy from 01\/01\/2012\u201301\/09\/2023, utilising administrative databases covering around 10 million inhabitants. Adult patients were included having at least one ICU discharge diagnosis of IFI at their first IFI\u2010related hospitalisation and having at least 12\u2009months of available data prior to this hospitalisation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 746 IFI patients discharged from ICU (incidence of 4.0 per 1000 ICU\u2010hospitalised patients), were included. Median age was 68\u2009years, 63% were males, and the overall Charlson Comorbidity Index was 2.2. The top three diagnoses were candidiasis (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009501, 2.7\/1000 ICU\u2010hospitalised patients), aspergillosis (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200971, 0.4\/1000), and pneumocystosis (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200955, 0.3\/1000). The evaluation of the comorbidity profile in IFI patients revealed the presence of hypertension (60.5%), use of systemic GC\/antibacterials (45.3% during 12\u2009months before and 18.6% during 3\u2009months before hospital admission), cancer (23.1%), diabetes (24.3%) and cardiovascular diseases (23.9%). The mean (\u00b1SD) length of hospitalisation in ICU was 19.9\u2009\u00b1\u200924.1\u2009days (median 11\u2009days), and deaths occurred in 36.1% of IFI patients (within 30\u2009days from discharge).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This retrospective analysis among ICU\u2010hospitalised patients described the burden of IFI in ICU, and its understanding could be crucial to strengthen surveillance, investments in research, and public health interventions as required by WHO.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.13779","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T08:44:45Z","timestamp":1722847485000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A retrospective Italian analysis on the characteristics of invasive fungal infections in the intensive care unit setting:\n                    <scp>CHARTER<\/scp>\n                    \u2010\n                    <scp>IFI<\/scp>\n                    study"],"prefix":"10.1111","volume":"67","author":[{"given":"Pier Luigi","family":"Viale","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, Department of Medical and Surgical Sciences, Sant'Orsola\u2010Malpighi Hospital University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Mirandola","sequence":"additional","affiliation":[{"name":"Gilead Sciences, Medical Affairs  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciro","family":"Natalini","sequence":"additional","affiliation":[{"name":"Gilead Sciences, Medical Affairs  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca Degli","family":"Esposti","sequence":"additional","affiliation":[{"name":"CliCon Societ\u00e0 Benefit S.r.l Health Economics &amp; Outcomes Research  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melania","family":"Dovizio","sequence":"additional","affiliation":[{"name":"CliCon Societ\u00e0 Benefit S.r.l Health Economics &amp; Outcomes Research  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2852-2022","authenticated-orcid":false,"given":"Chiara","family":"Veronesi","sequence":"additional","affiliation":[{"name":"CliCon Societ\u00e0 Benefit S.r.l Health Economics &amp; Outcomes Research  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Forcina","sequence":"additional","affiliation":[{"name":"Gilead Sciences, Medical Affairs  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Navalesi","sequence":"additional","affiliation":[{"name":"Institute of Anaesthesia and Intensive Care Unit Padua University Hospital  Padua Italy"},{"name":"Department of Medicine University of Padua Medical School  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Boscolo","sequence":"additional","affiliation":[{"name":"Institute of Anaesthesia and Intensive Care Unit Padua University Hospital  Padua Italy"},{"name":"Department of Medicine University of Padua Medical School  Padua Italy"},{"name":"Thoracic Surgery and Lung Transplant Unit\u2014Department of Cardiac, Thoracic, Vascular Sciences, and Public Health University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/S15010-021-01640-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/JOF3040057"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S390946"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/S12281-022-00432-2"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JMII.2022.12.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30847-1"},{"key":"e_1_2_9_8_1","unstructured":"World Health Organization.WHO fungal priority pathogens list to guide research development and public health action.2022."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/S13054-019-2497-3"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/MMY\/MYAD074"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30274-1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/JOF7121067\/S1"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2017.07.008"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CHEST.2021.08.081"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/S15010-013-0432-0"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1439-0507.2011.02044.X"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00134-017-4731-2"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/S-0041-1739472\/ID\/JR220206-21"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/CID\/CIAA1065"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1086\/378745\/2"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/S10096-006-0159-2"},{"key":"e_1_2_9_23_1","unstructured":"WHO.WHO Director\u2010General's opening remarks at the media briefing on COVID\u201019\u201411 March 2020. Accessed February 28 2024.https:\/\/www.who.int\/director\u2010general\/speeches\/detail\/who\u2010director\u2010general\u2010s\u2010opening\u2010remarks\u2010at\u2010the\u2010media\u2010briefing\u2010on\u2010covid\u201019\u2010\u2010\u201011\u2010march\u20102020"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T09:06:10Z","timestamp":1755507970000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.13779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/myc.13779"],"URL":"https:\/\/doi.org\/10.1111\/myc.13779","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"2024-04-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13779"}}