{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T23:06:35Z","timestamp":1768345595773,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Invasive fungal diseases (IFD) are high morbidity and mortality infections in children with cancer suffering episodes of high\u2010risk febrile neutropenia (HRFN). IFD epidemiology has changed in the last two decades, with an increasing incidence in recent years due to the growing number of immunocompromised children at risk for IFD. The aim of this study was to evaluate the incidence of IFD in children with cancer in the period 2016\u20132020 compared to 2004\u20132006 in six hospitals in Chile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective, multicentre study, carried out between 2016 and 2020 in six hospitals in Chile. The defined cohort corresponds to a dynamic group of HRFN episodes in patients &lt;18\u2009years old with cancer, who at the fourth day of evolution still presented fever and neutropenia (persistent HRFN). Each episode was followed until resolution of FN. The incidence of IFD was calculated between 2016 and 2020 and compared with data obtained in the period 2004\u20132006. The incidence rate was estimated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 777 episodes of HRFN were analysed; 257 (33.1%) were considered as persistent\u2010HRFN occurring in 174 patients. The median age was 7\u2009years (IQR: 3\u201312\u2009years) and 52.3% (<jats:italic>N<\/jats:italic>\u2009=\u200991) were male. Fifty\u2010three episodes of IFD were detected: 21 proven, 14 probable and 18 possible. Possible IFD were excluded, leaving 239 episodes of persistent\u2010HRFN with an IFD incidence of 14.6% (95% CI 10.5\u201319.9) and an incidence rate of 13.6 IFD cases per 1000\u2009days of neutropenia (95% CI 9.5\u201320.0). Compared to 2004\u20132006 cohort (incidence: 8.5% (95% CI 5.2\u201313.5)), a significant increase in incidence of 6.1% (95% CI 0.2\u201312.1, <jats:italic>p<\/jats:italic>\u2009=\u2009.047) was detected in cohorts between 2016 and 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We observed a significant increase in IFD in 2016\u20132020, compared to 2004\u20132006 period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13780","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T07:19:36Z","timestamp":1723447176000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Epidemiological changes of invasive fungal disease in children with cancer: Prospective study of the National Child Program of Antineoplastic Drugs network, Chile"],"prefix":"10.1111","volume":"67","author":[{"given":"Marlon","family":"Barraza","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy Hospital Dr. Luis Calvo Mackenna  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romina","family":"Valenzuela","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Hospital Dr. Luis Calvo Mackenna Universidad de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"Villarroel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Hospital Dr. Luis Calvo Mackenna Universidad de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"de la Maza","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Hospital Dr. Luis Calvo Mackenna Universidad de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Contardo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Hospital Dr. Roberto del R\u00edo Universidad de Chile  Santiago Chile"},{"name":"Committee of Infectious Diseases National Child Program of Antineoplastic Drugs (PINDA)  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Mar\u00eda","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Committee of Infectious Diseases National Child Program of Antineoplastic Drugs (PINDA)  Santiago Chile"},{"name":"Department of Pediatrics Hospital San Juan de Dios  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Committee of Infectious Diseases National Child Program of Antineoplastic Drugs (PINDA)  Santiago Chile"},{"name":"Department of Pediatrics, Faculty of Medicine, Hospital Dr. S\u00f3tero del R\u00edo Pontificia Universidad Cat\u00f3lica  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Zubieta","sequence":"additional","affiliation":[{"name":"Committee of Infectious Diseases National Child Program of Antineoplastic Drugs (PINDA)  Santiago Chile"},{"name":"Department of Pediatrics Hospital Dr. Exequiel Gonz\u00e1lez Cort\u00e9s  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Committee of Infectious Diseases National Child Program of Antineoplastic Drugs (PINDA)  Santiago Chile"},{"name":"Department of Pediatrics, Faculty of Medicine, Hospital San Borja Arriar\u00e1n Universidad de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda E.","family":"Santolaya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Hospital Dr. Luis Calvo Mackenna Universidad de Chile  Santiago Chile"},{"name":"Committee of Infectious Diseases National Child Program of Antineoplastic Drugs (PINDA)  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky244"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1586\/eri.11.1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-023-08314-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27564"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-023-00926-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001468"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00681"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181e7db7f"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/pix046"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.02224"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0716-10182021000600857"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002641"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27915"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.29275"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181864a80"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12910"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000002242"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01768-x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0212924"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13780","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T09:06:07Z","timestamp":1755507967000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.13780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/myc.13780"],"URL":"https:\/\/doi.org\/10.1111\/myc.13780","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"2024-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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