{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:17:27Z","timestamp":1780057047204,"version":"3.54.0"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sensitization to <jats:italic>Aspergillus fumigatus<\/jats:italic> (AS) has been recently described in chronic obstructive pulmonary disease (COPD) patients. However, there is no data on the community prevalence of AS in COPD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the prevalence of AS among COPD subjects. The secondary objectives were to (1) assess the prevalence of allergic bronchopulmonary aspergillosis (ABPA) in COPD and (2) compare the lung function in COPD subjects with and without AS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a cross\u2010sectional study in rural (29 villages) and urban (20 wards) communities in North India. We identified individuals with respiratory symptoms (IRS) through a house\u2010to\u2010house survey using a modified IUATLD questionnaire. We then diagnosed COPD through specialist assessment and spirometry using the GOLD criteria. We assayed <jats:italic>A.fumigatus<\/jats:italic>\u2010specific IgE in COPD subjects. In those with <jats:italic>A. fumigatus<\/jats:italic>\u2010specific IgE \u22650.35 kUA\/L (AS), ABPA was diagnosed with raised serum total IgE and raised <jats:italic>A.fumigatus<\/jats:italic>\u2010specific IgG or blood eosinophil count.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found 1315 (8.2%) IRS among 16,071 participants &gt;40\u2009years and diagnosed COPD in 355 (2.2%) subjects. 291 (82.0%) were men and 259 (73.0%) resided in rural areas. The prevalence of AS and ABPA was 17.7% (95% CI, 13.9\u201321.8) and 6.6% (95% CI, 4.4\u20138.8). We found a lower percentage predicted FEV1 in COPD subjects with AS than those without (<jats:italic>p<\/jats:italic>\u2009=.042).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found an 18% community prevalence of AS in COPD subjects in a specific area in North India. Studies from different geographical areas are required to confirm our findings. The impact of AS and ABPA on COPD requires further research.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13784","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T23:59:37Z","timestamp":1723247977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Population prevalence of aspergillus sensitization and allergic bronchopulmonary aspergillosis in COPD subjects in North India"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4839-0138","authenticated-orcid":false,"given":"Kathirvel","family":"Soundappan","sequence":"first","affiliation":[{"name":"Department of Community Medicine and School of Public Health Postgraduate institute of medical education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0410-8468","authenticated-orcid":false,"given":"Valliappan","family":"Muthu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate institute of medical education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahajal","family":"Dhooria","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate institute of medical education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6505-6019","authenticated-orcid":false,"given":"Inderpaul Singh","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate institute of medical education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuruswamy Thurai","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate institute of medical education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9097-9253","authenticated-orcid":false,"given":"Shivaprakash Mandya","family":"Rudramurthy","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Postgraduate institute of medical education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1555-3807","authenticated-orcid":false,"given":"Arunaloke","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Postgraduate institute of medical education and Research  Chandigarh India"},{"name":"Doodhadhari Burfani Hospital  Haridwar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh N.","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate institute of medical education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritesh","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate institute of medical education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(18)30409-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.07.2165"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00162912"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-014-0130-1"},{"issue":"8","key":"e_1_2_9_6_1","first-page":"936","article-title":"Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis in patients with bronchial asthma: systematic review and meta\u2010analysis","volume":"13","author":"Agarwal R","year":"2009","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2023.08.004"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2023.04.009"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/lungindia.lungindia_300_18"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.14299"},{"key":"e_1_2_9_11_1","unstructured":"Global Initiative for Chronic Obstructive Lung Disease (GOLD).Global Strategy for Prevention Diagnosis and Management of COPD: 2023. Report.https:\/\/goldcopd.org\/2023\u2010gold\u2010report\u20102\/(Last accessed 26 December 2023)"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v4.i4.141"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00061-2024"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.861866"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000755"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-020-01259-8"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693781003743148"},{"issue":"4","key":"e_1_2_9_18_1","first-page":"136","article-title":"The prevalence of aspergillus skin hypersensitivity in patients of COPD versus healthy controls","volume":"6","author":"Chopra V","year":"2017","journal-title":"International Journal of Scientific Research"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-0069"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.13.0838"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.640289"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12605"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.4103\/lungindia.lungindia_148_23"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13784","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T09:05:50Z","timestamp":1755507950000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.13784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/myc.13784"],"URL":"https:\/\/doi.org\/10.1111\/myc.13784","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"2024-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13784"}}