{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:20:17Z","timestamp":1791958817200,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T00:00:00Z","timestamp":1726358400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chromoblastomycosis (CBM) is a chronic infection of skin and subcutaneous tissue. CBM cases have been reported in local literature from Pakistan with heterogenous demographic, diagnostic and therapeutic information. The objective of this study is to share the experience of CBM from a large tertiary care hospital laboratory in Pakistan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This was a retrospective observational study. Histopathology and microbiology data of suspected CBM between 2016 and 2022 was retrieved. Patients' demographics, site of involvement, histopathological findings and positive microbiology cultures were assessed. Literature search on Google Scholar, PubMed and PakMediNet was done between 1990 and 2023 with multiple terms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>A total of 16 CBM cases were identified; 14 were histopathology positive and two were both histopathology and culture positive. The median age was 21\u2009years, and 11 patients were male. The predominant site was lower extremities followed by the face. Severe acanthosis, hyperkeratosis and granuloma with sclerotic bodies were observed in all histopathology slides. <jats:italic>Alternaria<\/jats:italic> spp. and <jats:italic>Phialophora<\/jats:italic> spp. were isolated from two culture\u2010positive cases. A total of nine cases of CBM were reported from Pakistan in PubMed non\u2010indexed journal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CBM is not a commonly thought of disease when evaluating skin lesions in Pakistan. A high index of suspicion when assessing patients who may have a history of trauma, exposure to soil and suggestive lesions is reasonable. An integrated approach between clinicians, histopathologist and microbiologist is required to do early identification and therapeutic interventions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13796","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T02:23:51Z","timestamp":1726453431000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Chromoblastomycosis: A Single Centre Clinical Laboratory Experience of Seven Years (2016\u20132022) and Literature Review From Pakistan"],"prefix":"10.1111","volume":"67","author":[{"given":"Mohammad","family":"Zeeshan","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Aga Khan University  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saira","family":"Fatima","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Aga Khan University  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joveria","family":"Farooqi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Aga Khan University  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabiya","family":"Owais","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Aga Khan University  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arsalan","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Aga Khan University  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2497-7847","authenticated-orcid":false,"given":"Kausar","family":"Jabeen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Aga Khan University  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afia","family":"Zafar","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Aga Khan University  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,15]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Ending the Neglect to Attain the Sustainable Development Goals: A Rationale for Continued Investment in Tackling Neglected Tropical Diseases 2021\u20132030","author":"World Health Organization","year":"2022"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13225-020-00452-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2003.15.Supplement-2.36"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009611"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00032-16"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9742832"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30306-7"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04711.x"},{"key":"e_1_2_9_10_1","first-page":"1390","article-title":"A Rare Case of Chromoblastomycosis in a 12\u2010Year\u2010Old Boy","volume":"12","author":"Khan S.","year":"2019","journal-title":"Journal of Pakistan Medical Association"},{"issue":"3","key":"e_1_2_9_11_1","first-page":"27","article-title":"Chromomycosis: A Pigmented Fungal Infection Mimicking Squamous Cell Carcinoma of Skin","volume":"9","author":"Suhail M.","year":"1999","journal-title":"Journal of Pakistan Association of Dermatologists"},{"key":"e_1_2_9_12_1","first-page":"44","article-title":"Chromoblastomycosis: An Unusual Cutaneous Dematiaceous Fungal Infection","volume":"19","author":"Aslam M. H. R.","year":"2003","journal-title":"Biom\u00e9dica"},{"issue":"1","key":"e_1_2_9_13_1","first-page":"54","article-title":"Squamous Cell Carcinoma Foot Arising in Deep Mycosis [Chromomycosis] A Case Report","volume":"9","author":"Shahid M.","year":"2004","journal-title":"Journal of Surgery Pakistan"},{"issue":"2","key":"e_1_2_9_14_1","first-page":"122","article-title":"Clinicopathological Study of Cutaneous Chromoblastomycosis in Pakistan","volume":"22","author":"Khan I.","year":"2012","journal-title":"Journal of Pakistan Association of Dermatologists"},{"issue":"4","key":"e_1_2_9_15_1","first-page":"379","article-title":"Chromoblastomycosis With Skeletal Involvement: A Case Report","volume":"26","author":"Javaid S.","year":"2016","journal-title":"Journal of Pakistan Association of Dermatologists"},{"issue":"8","key":"e_1_2_9_16_1","article-title":"Diagnosis of Cutaneous Chromoblastomycosis and Its Response to Amphotericin B Therapy: A Case Report","volume":"14","author":"Haq F. U.","year":"2022","journal-title":"Cureus"},{"issue":"2","key":"e_1_2_9_17_1","first-page":"764","article-title":"Verrucous and Ulcerovagitant Facial Chromo\u2010Blastomycosis With Nasal Bridge Destruction, Cleaving Upper Lip Deformity and Exuberant Eyelid Squamous Cell Carcinoma\u2010Rare Debilitating Sequel of Facial Chromoblastomycosis in a Non\u2010Endemic Region: A Case Report","volume":"33","author":"Chaudhry Z. S.","year":"2023","journal-title":"Journal of Pakistan Association of Dermatologists"},{"issue":"3","key":"e_1_2_9_18_1","first-page":"503","article-title":"Chromoblastomycosis: A Rare Presentation With Polymorphic Cutaneous Lesions and Bone Involvement, Caused by Exophiala janselmei","volume":"35","author":"Mansoor M.","year":"2023","journal-title":"Journal of Ayub Medical College Abbottabad\u2010Pakistan"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgph.0001893"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102325"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myab062"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13796","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T05:50:56Z","timestamp":1727416256000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.13796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/myc.13796"],"URL":"https:\/\/doi.org\/10.1111\/myc.13796","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"2024-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13796"}}