{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T01:39:44Z","timestamp":1788053984710,"version":"build-2784847793"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Invasive candidiasis (IC) represents a significant threat to both mortality and morbidity, especially among vulnerable populations. Intra\u2010abdominal candidiasis (IAC) frequently occurs in critically ill and cancer patients, with these specific groups carrying a heightened risk for such invasive fungal infections. Despite this, there is a noticeable lack of attention to IAC in cancer patients within the literature, highlighting a critical gap that requires urgent consideration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to explore the clinical and epidemiological characteristics of IAC and identify prognostic factors in a cancer centre in a middle\u2010income country over 10\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>A retrospective cohort observational study of adults diagnosed with IAC was conducted at the Instituto do Cancer do Estado de S\u00e3o Paulo (ICESP), a tertiary hospital specialising in oncological diseases with 499 beds, including 85 intensive care unit (ICU) beds, from December 2009 through May 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 128 episodes were included: 67.2% admitted to the ICU; 54.7% males; and median age 62\u2009years. The predominant diagnosis was peritonitis (75.8%). Blood culture samples were collected from 128 patients upon admission, revealing candidemia in 17.2% (22). The most frequently isolated were <jats:italic>C. albicans<\/jats:italic> (<jats:italic>n<\/jats:italic>\u2009=\u200965, 50.8%) and <jats:italic>C. glabrata<\/jats:italic> (<jats:italic>n<\/jats:italic>\u2009=\u200942, 32.8%). Antifungal treatment was administered to 91 (71%) patients, with fluconazole (64.8%) and echinocandins (23.4%) being the most common choices. A significant proportion of these patients had a history of abdominal surgery or antibiotic use. Independent factors associated with 30\u2010day mortality included the median Sequential Organ Failure Assessment (SOFA) score of 6 (OR\u2009=\u20091.30, 95% CI 1.094\u20131.562, <jats:italic>p<\/jats:italic>\u2009=\u20090.003), days of treatment (median 10.5) (OR\u2009=\u20090.93, 95% CI 0.870\u20130.993, <jats:italic>p<\/jats:italic>\u2009=\u20090.031) and abdominal source control (78.1%) (OR\u2009=\u20090.148, 95% CI 0.030\u20130.719, <jats:italic>p<\/jats:italic>\u2009=\u20090.018). The 30\u2010day mortality rate was 41.1%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study underscores the critical importance of implementing effective source control as a key strategy for reducing mortality in IAC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13807","type":"journal-article","created":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T02:58:53Z","timestamp":1729911533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Intra\u2010Abdominal Candidiasis in Cancer Patients: A 10\u2010Year Experience in a Middle\u2010Income Country"],"prefix":"10.1111","volume":"67","author":[{"given":"Bianca\u00a0Leal","family":"de Almeida","sequence":"first","affiliation":[{"name":"Instituto do Cancer do Estado de Sao Paulo, School of Medicine, Hospital Infection Control and Infectious Diseases Service University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor\u00a0Ciampone","family":"Arcieri","sequence":"additional","affiliation":[{"name":"Department of Infectious and Parasitic Diseases, School of Medicine University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo\u00a0Mardegam","family":"Razente","sequence":"additional","affiliation":[{"name":"Instituto do Cancer do Estado de Sao Paulo, School of Medicine, Hospital Infection Control and Infectious Diseases Service University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maristela\u00a0Pinheiro","family":"Freire","sequence":"additional","affiliation":[{"name":"Instituto do Cancer do Estado de Sao Paulo, School of Medicine, Hospital Infection Control and Infectious Diseases Service University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Infection Control Department, Hospital das Cl\u00ednicas University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Infection Control Department, Hospital das Cl\u00ednicas University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelina\u00a0da\u00a0Motta\u00a0Pacheco\u00a0Alves\u00a0de","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Pathology Department Laborat\u00f3rio de Microbiologia da Divis\u00e3o de Laborat\u00f3rio Central, Hospital das Cl\u00ednicas da Faculdade de Medicina USP (FMUSP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edson","family":"Abdala","sequence":"additional","affiliation":[{"name":"Instituto do Cancer do Estado de Sao Paulo, School of Medicine, Hospital Infection Control and Infectious Diseases Service University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Department of Infectious and Parasitic Diseases, School of Medicine University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7996-8265","authenticated-orcid":false,"given":"Marcello\u00a0Mihailenko\u00a0Chaves","family":"Magri","sequence":"additional","affiliation":[{"name":"Department of Infectious and Parasitic Diseases, School of Medicine University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4161\/viru.26187"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-024-00503-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-024-07341-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1315399"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1754"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2497-3"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-013-3109-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-3866-2"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.137.12.1341"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2023.149"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-04220-6_4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-021-00585-6"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-020-05380-x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-016-2775-9"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof9040468"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12695"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0221033"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof10040268"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofy358"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ933"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153247"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/21548331.2019.1677032"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T09:09:41Z","timestamp":1730192981000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.13807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/myc.13807"],"URL":"https:\/\/doi.org\/10.1111\/myc.13807","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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