{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:50:04Z","timestamp":1791557404394,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:00:00Z","timestamp":1731628800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Trichophyton indotineae<\/jats:italic>, a newly defined species within the <jats:italic>T.\u2009mentagrophytes<\/jats:italic>\/<jats:italic>T.\u2009interdigitale<\/jats:italic> complex, has emerged as an epidemiological concern worldwide. However, owing to the limitations of commonly applied fungal identification techniques, <jats:italic>T.\u2009indotineae<\/jats:italic> remains underreported. In addition, <jats:italic>T.\u2009indotineae<\/jats:italic>'s response to treatment has been described in only a few studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the prevalence, clinical characteristics and treatment outcomes of terbinafine\u2010resistant <jats:italic>T.\u2009mentagrophytes<\/jats:italic>\/<jats:italic>T.\u2009interdigitale<\/jats:italic> complex infections, as well as to detect <jats:italic>T.\u2009indotineae<\/jats:italic> cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>A retrospective cohort study was conducted on 22 patients with <jats:italic>T.\u2009mentagrophytes<\/jats:italic>\/<jats:italic>T.\u2009interdigitale<\/jats:italic> complex infections between 2019 and 2023, using either culture or commercial polymerase chain reaction methods. Patient demographics, disease characteristics and treatment responses were recorded. Patients non\u2010responsive to oral terbinafine underwent further analyses, including DNA sequencing of the internal transcribed spacer region for accurate species identification and mutational analysis of the squalene epoxidase (<jats:italic>SQLE<\/jats:italic>) gene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the patients was 49.7\u2009years (\u00b118.2), with 54.5% men. Terbinafine\u2010resistant <jats:italic>T.\u2009mentagrophytes<\/jats:italic>\/<jats:italic>T.\u2009interdigitale<\/jats:italic> complex infections were reported in 46.2% of the cohort (<jats:italic>n<\/jats:italic>\u2009=\u20096\/13 patients; 9 lost to treatment response follow\u2010up), all of whom exhibited extensive dermatophytosis. Among the terbinafine\u2010resistant <jats:italic>T.\u2009mentagrophytes<\/jats:italic>\/<jats:italic>T.\u2009interdigitale<\/jats:italic> isolates, all five isolates available for fungal analysis were identified as <jats:italic>T.\u2009indotineae<\/jats:italic>, harbouring <jats:italic>SQLE<\/jats:italic> single\u2010point mutations (Phe397Leu and Leu393Ser). Only three of the terbinafine\u2010resistant cases responded to oral itraconazole 200\u2009mg\/day, with two responding only to oral voriconazole and one to oral itraconazole 400\u2009mg\/day.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>All cases of <jats:italic>T.\u2009mentagrophytes<\/jats:italic>\/<jats:italic>T.\u2009interdigitale<\/jats:italic> assessed in this study were identified as <jats:italic>T.\u2009indotineae<\/jats:italic>, which exhibits <jats:italic>SQLE<\/jats:italic> gene mutations. This underscores the importance of integrating methods to detect <jats:italic>T.\u2009indotineae<\/jats:italic> in routine clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13812","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T03:30:37Z","timestamp":1731727837000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["First Reported Cases of Terbinafine\u2010Resistant <i>Trichophyton indotineae<\/i> Isolates in Israel: Epidemiology, Clinical Characteristics and Response to Treatment"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1518-6875","authenticated-orcid":false,"given":"Eran","family":"Galili","sequence":"first","affiliation":[{"name":"Department of Dermatology Sheba Medical Center  Ramat\u2010Gan Israel"},{"name":"Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irit","family":"Lubitz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"Clinical Microbiology Sheba Medical Center  Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avner","family":"Shemer","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sheba Medical Center  Ramat\u2010Gan Israel"},{"name":"Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadav","family":"Astman","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sheba Medical Center  Ramat\u2010Gan Israel"},{"name":"Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keren","family":"Pevzner","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sheba Medical Center  Ramat\u2010Gan Israel"},{"name":"Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeala","family":"Gazit","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"Clinical Microbiology Sheba Medical Center  Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oz","family":"Segal","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sheba Medical Center  Ramat\u2010Gan Israel"},{"name":"Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lyakhovitsky","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sheba Medical Center  Ramat\u2010Gan Israel"},{"name":"Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiraz","family":"Halevi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"Clinical Microbiology Sheba Medical Center  Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Baum","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sheba Medical Center  Ramat\u2010Gan Israel"},{"name":"Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviv","family":"Barzilai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sheba Medical Center  Ramat\u2010Gan Israel"},{"name":"Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Amit","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"Clinical Microbiology Sheba Medical Center  Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-016-0082-8"},{"issue":"8","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","DOI":"10.1128\/jcm.00562-23","article-title":"Terbinafine\u2010Resistant Dermatophytes and the Presence of Trichophyton indotineae in North America","volume":"61","author":"Ca\u00f1ete\u2010Gibas C. 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