{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T08:45:28Z","timestamp":1696063528309},"reference-count":25,"publisher":"Wiley","issue":"7-8","license":[{"start":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T00:00:00Z","timestamp":1513641600000},"content-version":"vor","delay-in-days":10033,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[1990,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The differentiation between a chronic cryptococcal meningitis and a chronic tuberculous meningitis may cause problems for the clinician only if standard microbiological methods are not applied to the diagnosis of both infections.<\/jats:p><jats:p>In a male non\u2010AIDS patient (50 y), 11 years after a suggested diagnosis of \u201ctuberculous meningitis\u201d, meningoencephalitis with hydrocephalus was diagnosed and treated accordingly without success. <jats:italic>Mycobacterium tuberculosis<\/jats:italic> was never found. Because fibrin fibres of a spider web coagulum in the CSF resembled <jats:italic>Aspergillus<\/jats:italic> mycelium, the patient was then treated with amphotericin B + flucytosine. Finally, a mycological examination led to the true diagnosis: (1) In the CSF, resembling <jats:italic>Aspergillus<\/jats:italic> hyphae were found to be spider web coagulum fibres. (2) Cryptococcal meningoencephalitis based on the detection of <jats:italic>Cryptococcus neoformans<\/jats:italic> in CSF and its antigen in serum and CSF. \u2010 At post\u2010mortem, cryptococcal meningoencephalitis was established as cause of death. Residual signs of tuberculosis could not be detected in the brain and the meninges. Common clinical similarities of cryptococcal and tuberculous meningitis and the possibility of a double infection are discussed. A comparison of the presence of <jats:italic>Cr. neoformans<\/jats:italic> in the meninges of non\u2010AIDS and AIDS patients is made. The formation of spider web coagulum in the CSF is discussed. Proposals for the diagnosis, therapy and prophylaxis of cryptococcal meningitis are made.<\/jats:p>","DOI":"10.1111\/myc.1990.33.7-8.359","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T08:37:40Z","timestamp":1514018260000},"page":"359-367","source":"Crossref","is-referenced-by-count":1,"title":["Cerebrospinal fluid indices in cryptococcal and tuberculous meningitis: The spider web coagulum and its diagnostic significance"],"prefix":"10.1111","volume":"33","author":[{"given":"F.","family":"Staib","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Seibold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Antweiler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Zimmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Heitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Stoltenburg-Didinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,19]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"4231","volume-title":"Neurologie in Praxis und Klinik, Bd","author":"Bammer H. 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Immunol."},{"key":"e_1_2_1_19_1","first-page":"363","article-title":"Cryptococcosis in AIDS - Mycological-diagnostic and epidemiological observations","volume":"2","author":"Staib F.","year":"1987","journal-title":"AIDS-Forschung (Aifo)"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1988.tb03864.x"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00314216"},{"key":"e_1_2_1_22_1","unstructured":"1963 Springer Handbuch der Kinderheilkunde Bd. V Infektionskrankheiten Berlin G\u00f6ttingen - Heidelberg F. Schmid H. Opitz F. Schmid Immunbiologie der Tuberkulose 646 661"},{"key":"e_1_2_1_23_1","first-page":"46","article-title":"Cryptococcosis and AIDS. Autopsy material and its significance for the mycological evaluation of the efficacy of the therapy with amphotericin B + flucytosine","volume":"5","author":"Staib F.","year":"1988","journal-title":"Rev. Iber. 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