{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:41:14Z","timestamp":1753879274294,"version":"3.41.2"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Access to fungal disease diagnosis is crucial for reducing mortality, yet it varies widely across Argentina, especially outside Buenos Aires. In regions like Santa Fe and Paran\u00e1, where most healthcare facilities are under 150 beds, maintaining specialised mycology labs is challenging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This work describes the establishment and first\u2010year results of a centralised Fungal Disease Response Centre (FDRC) and referral network serving this region, covering approximately 1 million inhabitants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The FDRC provided tests from the WHO's Essential Diagnostic List, along with antifungal susceptibility testing and molecular diagnostics. Additionally, we offered continuous training, a courier service and digital tools for service requests and result reporting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 2023, the FDRC handled samples from 878 patients from 22 institutions, performing 1151 tests on 897 samples. Common tests included <jats:italic>Aspergillus<\/jats:italic> galactomannan quantification and molecular diagnostics, diagnosing 101 fungal infections including fungaemias, histoplasmosis, aspergillosis and deep\u2010seated candidiasis. Average turnaround times were 6.2\u2009h for antigen\u2010based tests and 21.5\u2009h for molecular tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This centralised service improved diagnosis speed and quality, overcoming limitations of smaller labs. It also enabled population\u2010based studies, revealing higher\u2010than\u2010expected histoplasmosis prevalence. The FDRC's first\u2010year results demonstrate that regional centralisation can enhance diagnostic quality, improve patient outcomes and advance epidemiological knowledge.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.70027","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T04:33:37Z","timestamp":1737520417000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fungal Disease Response Centre: Pioneering Diagnostic Approach for Regions With Dispersed Hospital Centres"],"prefix":"10.1111","volume":"68","author":[{"given":"Manuela","family":"Loaiza\u2010Oliva","sequence":"first","affiliation":[{"name":"Laboratorio de Micolog\u00eda y Diagn\u00f3stico Molecular\u2014C\u00e1tedra de Parasitolog\u00eda y Micolog\u00eda\u2014Bioqu\u00edmica Universidad Nacional del Litoral  Santa Fe Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)  Santa Fe Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soledad","family":"Gamarra","sequence":"additional","affiliation":[{"name":"Laboratorio de Micolog\u00eda y Diagn\u00f3stico Molecular\u2014C\u00e1tedra de Parasitolog\u00eda y Micolog\u00eda\u2014Bioqu\u00edmica Universidad Nacional del Litoral  Santa Fe Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mat\u00edas","family":"Cabeza","sequence":"additional","affiliation":[{"name":"Laboratorio de Micolog\u00eda y Diagn\u00f3stico Molecular\u2014C\u00e1tedra de Parasitolog\u00eda y Micolog\u00eda\u2014Bioqu\u00edmica Universidad Nacional del Litoral  Santa Fe Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)  Santa Fe Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Alastruey\u2010Izquierdo","sequence":"additional","affiliation":[{"name":"Mycology Reference Laboratory, National Centre for Microbiology Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Luis","family":"Rodr\u00edguez\u2010Tudela","sequence":"additional","affiliation":[{"name":"Global Action for Fungal Infections  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3927-4650","authenticated-orcid":false,"given":"Guillermo","family":"Garcia\u2010Effron","sequence":"additional","affiliation":[{"name":"Laboratorio de Micolog\u00eda y Diagn\u00f3stico Molecular\u2014C\u00e1tedra de Parasitolog\u00eda y Micolog\u00eda\u2014Bioqu\u00edmica Universidad Nacional del Litoral  Santa Fe Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)  Santa Fe Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"GAFFI \u201cBurden of Disease Maps\u2014Gaffi\u2014Global Action Fund for Fungal Infections \u201dhttps:\/\/gaffi.org\/why\/burden\u2010of\u2010disease\u2010maps\/."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(17)30308\u20100"},{"key":"e_1_2_7_4_1","unstructured":"World\u2010Bank \u201cPIB per C\u00e1pita (US$ a Precios Actuales)\u2014Argentina \u201dhttps:\/\/datos.bancomundial.org\/indicator\/NY.GDP.PCAP.CD?locations=AR."},{"key":"e_1_2_7_5_1","unstructured":"Clinical and Laboratory Strandards Institute (CLSI) \u201cWayne P 2021. 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