{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:49:56Z","timestamp":1790232596586,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T00:00:00Z","timestamp":1739059200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Although there are some studies evaluating CIE incidence and associated risk factors, none assessed mortality several months after the <jats:italic>Candida<\/jats:italic> spp. BSI episode. We aimed to assess risk factors for CIE and outcomes, including 1\u2010year mortality, in patients with <jats:italic>Candida<\/jats:italic> spp. BSI in a public tertiary\u2010care teaching hospital in Brazil.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Retrospective case\u2013control, followed by a cohort study, with adult patients who presented a <jats:italic>Candida<\/jats:italic> spp. BSI. Participants were eligible if they had at least one echocardiogram performed no longer than 3\u2009days before <jats:italic>Candida<\/jats:italic> spp. BSI diagnosis and thereafter during the respective hospital admission. CIE diagnosis was defined by the presence of two major Duke criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We studied 164 patients (median age: 57.6\u2009years) with a median Charlson comorbidity index of 3 points. Most patients were female (54.9%), were on haemodialysis (54.9%), and 4.6% had a preexisting moderate\/severe heart valve disease. <jats:styled-content style=\"fixed-case\"><jats:italic>C. albicans<\/jats:italic><\/jats:styled-content> (36.2%) and <jats:styled-content style=\"fixed-case\"><jats:italic>C. parapsilosis<\/jats:italic><\/jats:styled-content> complex (34.4%) were the most frequent <jats:italic>Candida<\/jats:italic> species identified. CIE was detected in 10 patients (6.1%; 95% CI: 2.4%\u20139.8%). In the multivariable analysis, age and <jats:styled-content style=\"fixed-case\"><jats:italic>C. parapsilosis<\/jats:italic><\/jats:styled-content> complex remained as independent predictors of CIE. There was no significant difference between CIE and no CIE groups in 1\u2010year mortality after <jats:italic>Candida<\/jats:italic> spp. BSI diagnosis and hospital discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Considering the low costs and hazards associated with an echocardiogram, performing it systematically in all patients with <jats:italic>Candida<\/jats:italic> spp. BSI might improve CIE diagnosis and ultimately survival rates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.70032","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:15:03Z","timestamp":1739232903000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Candida Infective Endocarditis in Patients With <i>Candida<\/i> spp. Bloodstream Infection: Risk Factors and 1\u2010 Year Mortality"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6274-1320","authenticated-orcid":false,"given":"Tarsila","family":"Vieceli","sequence":"first","affiliation":[{"name":"Infectious Diseases Service Hospital de Cl\u00ednicas de Porto Alegre  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betina Maria","family":"Giordani","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service Hospital de Cl\u00ednicas de Porto Alegre  Porto Alegre Rio Grande do Sul Brazil"},{"name":"Internal Medicine Service Hospital de Cl\u00ednicas de Porto Alegre  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Azeredo","family":"de Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Internal Medicine Service Hospital de Cl\u00ednicas de Porto Alegre  Porto Alegre Rio Grande do Sul 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Rio Grande do Sul Brazil"},{"name":"Department of Internal Medicine Universidade Federal do Rio Grande do Sul  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1521-6608","authenticated-orcid":false,"given":"Fernando","family":"Pivatto J\u00fanior","sequence":"additional","affiliation":[{"name":"Internal Medicine Service Hospital de Cl\u00ednicas de Porto Alegre  Porto Alegre Rio Grande do Sul 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