{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T21:36:58Z","timestamp":1779313018423,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2025ZNSFSC1542"],"award-info":[{"award-number":["2025ZNSFSC1542"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mucormycosis is a life\u2010threatening fungal infection with high mortality in critically ill patients. Clinical manifestations and outcomes of mucormycosis in intensive care units (ICUs) remain poorly investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a multicenter retrospective study including 43 adult patients with confirmed mucormycosis admitted to 14 tertiary ICUs between January 2014 and May 2022. Clinical characteristics, diagnostic approaches, treatment strategies, and outcomes were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age was 56.8\u2009\u00b1\u200916.2\u2009years, with 16\/43 (37.2%) female patients. The 28\u2010day survival rate was 46.5% (20\/43). Lung involvement was predominant (29\/43, 67.4%), and 29\/43 (67.4%) patients received amphotericin B therapy. Survivors showed significantly better treatment response compared to non\u2010survivors (16\/20, 80% vs. 4\/23, 17.4%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Non\u2010survivors demonstrated significantly higher levels of aspartate aminotransferase, C\u2010reactive protein, and white blood cells, along with lower albumin levels. Metagenomic next\u2010generation sequencing (mNGS) was associated with a shorter time to diagnosis. Multivariate analysis identified age, respiratory failure, time from symptom onset to diagnosis, and antifungal treatment response as independent predictors of 28\u2010day mortality (AUC\u2009=\u20090.852).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In critically ill patients with mucormycosis, early diagnosis and prompt targeted therapy are crucial determinants of survival, with our newly developed prediction model providing a practical tool for risk stratification, while mNGS shows promise in expediting diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.70042","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T04:38:22Z","timestamp":1742704702000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Manifestations and Prognosis of Patients With Mucormycosis in Intensive Care Units in Western China: A Multi\u2010Center Retrospective Study"],"prefix":"10.1111","volume":"68","author":[{"given":"Fuxun","family":"Yang","sequence":"first","affiliation":[{"name":"Department of ICU, Sichuan Provincial People's Hospital University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of ICU, Sichuan Provincial People's Hospital University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit 903 Hospital  Mianyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital &amp; Institute, Sichuan Cancer Center University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicin Affiliated Hospital of North Sichuan Medical College  Nanchong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiani","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Chengdu Sixth People's Hospital  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sihan","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine People's Hospital of Tong Jiang Sichuan  Bazhong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianghai","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Second People's Hospital of Yibin  Yibin 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