{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:13:23Z","timestamp":1791807203529,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p><jats:italic>Candida auris<\/jats:italic> (<jats:styled-content style=\"fixed-case\"><jats:italic>C. auris<\/jats:italic><\/jats:styled-content>) is a therapeutic challenge due to the lack of definition of susceptibility breakpoints and the misidentification by biochemical tests, which leads to suboptimal therapy. Hence, our goal was to assess the treatment outcomes of <jats:styled-content style=\"fixed-case\"><jats:italic>C. auris<\/jats:italic><\/jats:styled-content> infections at our institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective observational study between January 2019 and June 2022 that included confirmed <jats:styled-content style=\"fixed-case\"><jats:italic>C. auris<\/jats:italic><\/jats:styled-content> infection cases. The primary endpoint was to assess the clinical outcomes of <jats:styled-content style=\"fixed-case\"><jats:italic>C. auris<\/jats:italic><\/jats:styled-content> management. The secondary endpoints were to evaluate mycologic cure, 30 and 90\u2010day infection recurrence, and 30\u2010day all\u2010cause mortality. Descriptive statistics were used to analyse our data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010six subjects were evaluated, with a mean age of 65.05\u2009\u00b1\u200916.86\u2009years. Candidemia accounted for 62.7% of cases. Clinical cure was achieved in 57% of patients, and mycologic cure in 84.4%. Recurrence of <jats:styled-content style=\"fixed-case\"><jats:italic>C. auris<\/jats:italic><\/jats:styled-content> infection occurred in 28.6% at 30\u2009days and in 12.7% at 90\u2009days. Thirty\u2010day all\u2010cause mortality occurred in 28.6% of patients. Multivariable logistic regression indicated that mycologic cure with Odds Ratio (OR) 6.96 (95% CI: 1.21\u201339.92), length in intensive care units (ICU) stay OR 0.132 (95% CI: 0.019\u20130.907), and baseline C\u2010reactive protein (CRP) OR 0.990 (95% CI: 0.982\u20130.998) were the independent predictors of clinical cure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Clinical cure of invasive <jats:styled-content style=\"fixed-case\"><jats:italic>C. auris<\/jats:italic><\/jats:styled-content> infections was dependent on mycologic cure, length of ICU stays, and baseline CRP levels, with observed 30\u2010day all\u2010cause mortality up to 28.6%. Similarly to other reports, our isolates exhibited resistance to fluconazole and amphotericin B in most cases. Only two isolates demonstrated resistance to caspofungin and were deemed pan\u2010resistant. Further multi\u2010centre studies are needed to validate our findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.70054","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T14:36:27Z","timestamp":1743690987000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Outcomes Amongst Patients Infected With Candida Auris: A Single\u2010Center Study"],"prefix":"10.1111","volume":"68","author":[{"given":"Sara","family":"Al Jabi","sequence":"first","affiliation":[{"name":"Cleveland Clinic Abu Dhabi  Abu Dhabi UAE"},{"name":"College of Medicine and Health Sciences United Arab Emirates University  Al Ain UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania","family":"El\u2010Lababidi","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Abu Dhabi  Abu Dhabi 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