{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:18:59Z","timestamp":1789611539637,"version":"build-2803163510"},"reference-count":66,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010mycobacterial residual lung abnormality (PMLA) from prior tuberculous (PTLA) or non\u2010tuberculous mycobacterial (PNTLA) lung infections predisposes to chronic pulmonary aspergillosis (CPA). However, the prevalence of CPA in patients with PMLA remains uncertain. We aimed to determine the prevalence of CPA in patients with PMLA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a systematic search of PubMed and Embase databases up to January 31, 2025, to identify studies reporting CPA prevalence in patients with PTLA or PNTLA (excluding those with active tuberculosis). The pooled prevalence was calculated using frequentist meta\u2010analysis (primary outcome), with Bayesian and trim\u2010and\u2010fill methods as sensitivity analyses. Study heterogeneity (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>) and publication bias were assessed. We performed multivariable meta\u2010regression to evaluate factors affecting heterogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010one studies (4172 PTLA and 13,905 PNTLA) were included. Frequentist meta\u2010analysis yielded a pooled CPA prevalence of 18% (95% confidence interval [CI], 11.6\u201325.4). Bayesian analysis with informative priors estimated prevalence of 7.1% (95% Credible Index, 4.5\u201310.4), and trim\u2010and\u2010fill adjustment for publication bias suggested prevalence to be 3.4% (95% CI, 0.69\u20137.7). On a multivariable analysis, we found CPA prevalence higher in hospital\u2010based studies, high TB burden settings and studies with prospective or cross\u2010sectional study designs; although CPA prevalence was higher in PTLA (23.1%) than in PNTLA (7%), it was not significantly different. We detected substantial heterogeneity (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200998.8%) and publication bias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is a high prevalence of CPA in patients with PMLA, particularly in TB\u2010endemic regions and hospital settings. Patients with PMLA should be routinely screened for CPA in high prevalence settings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.70060","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T07:39:37Z","timestamp":1745393977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Prevalence of Chronic Pulmonary Aspergillosis in Patients With Mycobacterial and Non\u2010Mycobacterial Tuberculosis Infection of the Lung: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6505-6019","authenticated-orcid":false,"given":"Inderpaul Singh","family":"Sehgal","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4839-0138","authenticated-orcid":false,"given":"Kathirvel","family":"Soundappan","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and School of Public Health Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2547-7668","authenticated-orcid":false,"given":"Ritesh","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0410-8468","authenticated-orcid":false,"given":"Valliappan","family":"Muthu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahajal","family":"Dhooria","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuruswamy Thurai","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut J. F.","family":"Salzer","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine\u2010Pneumology Kepler University Hospital, Medical Faculty, Johannes Kepler University  Linz Austria"},{"name":"Ignaz Semmelweis Institute  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9599-3137","authenticated-orcid":false,"given":"Oliver A.","family":"Cornely","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging\u2010Associated Diseases (CECAD) University of Cologne  Cologne Germany"},{"name":"Department I of Internal Medicine, Division of Infectious Diseases, Excellence Center for Medical Mycology (ECMM) University Hospital Cologne  Cologne Germany"},{"name":"German Centre for Infection Research (DZIF) Partner Site Bonn\u2010Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh Nath","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1555-3807","authenticated-orcid":false,"given":"Arunaloke","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Doodhadhari Burfani Hospital  Haridwar India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2020.1750956"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13746"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.70002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00692-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof3040057"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-024-00917-3"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13583"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.22.0526"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000001026"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.24.0165"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13747"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13695"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13711"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01184-2018"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-3879(70)90015-2"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.70034"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9020270"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2018.03.013"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_8_22_1","volume-title":"The Newcastle\u2010Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta\u2010Analyses","author":"Wells G.","year":"2000"},{"key":"e_1_2_8_23_1","first-page":"607","article-title":"Transformations Related to the Angular and the Square Root","volume":"17","author":"Freeman M. 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