{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:45:55Z","timestamp":1777430755094,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304041"],"award-info":[{"award-number":["82304041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972948"],"award-info":[{"award-number":["81972948"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:italic>Trichophyton mentagrophytes<\/jats:italic> complex species mainly cause superficial infections, with a high global incidence and affecting the quality of life of patients. The taxonomic identification between closely related species within the <jats:italic>T. mentagrophytes<\/jats:italic> complex remains problematic, especially between <jats:italic>T. mentagrophytes<\/jats:italic> and <jats:italic>T. interdigitale<\/jats:italic>. This study aimed to elucidate the species boundaries within the <jats:italic>T. mentagrophytes<\/jats:italic> complex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a phylogenetic tree, principal component analysis and population structure analysis based on whole genome single\u2010nucleotide polymorphism (SNP) data of 157\u2009<jats:italic>T. mentagrophytes<\/jats:italic> complex strains. The mating types, phenotypic and physiological characteristics of different populations of strains were detected to delimit the species within the complex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The phylogenomic analysis showed that the 157\u2009<jats:italic>T. mentagrophytes<\/jats:italic> complex strains were divided into five populations and clustered into three major clades, namely the <jats:italic>T. tonsurans<\/jats:italic> (population I), <jats:italic>T. interdigitale<\/jats:italic> (populations II, III and V) and <jats:italic>T.\u00a0mentagrophytes<\/jats:italic> (population IV) clades. <jats:italic>T. interdigitale<\/jats:italic> population III was significantly different from <jats:italic>T. interdigitale<\/jats:italic> population II in terms of nucleotide diversity, mating types, types of clinical disease caused and keratinolytic ability but similar to those of <jats:italic>T. mentagrophytes<\/jats:italic> population IV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>T. tonsurans<\/jats:italic>, <jats:italic>T. interdigitale<\/jats:italic> and <jats:italic>T. mentagrophytes<\/jats:italic> could be regarded as independent species and all strains were divided into five populations. The finding that <jats:italic>T. interdigitale<\/jats:italic> population III strains (<jats:italic>T<\/jats:italic>. <jats:italic>mentagrophytes<\/jats:italic> genotype Tm\u2010II*) are reclassified as <jats:italic>T. interdigitale<\/jats:italic> based on whole\u2010genome analysis is notable and clarifies previous confusion in clinical microbiology labs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.70066","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T01:11:05Z","timestamp":1749085865000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Species Distinction in the <i>Trichophyton mentagrophytes<\/i> Complex Based on Phylogenomic Analysis"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6762-1755","authenticated-orcid":false,"given":"Jin","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Peking University First Hospital  Beijing China"},{"name":"Research Center for Medical Mycology, Peking University  Beijing China"},{"name":"Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Peking University First Hospital  Beijing China"},{"name":"National Clinical Research Center for Skin and Immune Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Xu","sequence":"additional","affiliation":[{"name":"National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Geng","sequence":"additional","affiliation":[{"name":"National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1644-6942","authenticated-orcid":false,"given":"Yinggai","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Peking University First Hospital  Beijing China"},{"name":"Research Center for Medical Mycology, Peking University  Beijing China"},{"name":"Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Peking University First Hospital  Beijing China"},{"name":"National Clinical Research Center for Skin and Immune Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Peking University First Hospital  Beijing China"},{"name":"Research Center for Medical Mycology, Peking University  Beijing China"},{"name":"Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Peking University 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