{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:15:50Z","timestamp":1789172150348,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Serum 1,3\u2010\u03b2\u2010d\u2010glucan (BDG) tests are frequently used for diagnosing invasive candidiasis. However, BDG tests remain negative in many patients with candidemia, and factors influencing the probability for positive test results are poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To study clinical and microbiological factors predictive of a positive BDG test, as well as the association of a positive BDG test with mortality in patients with candidemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a retrospective cohort of patients with candidemia, BDG was analysed by the Glucatell assay and the Wako Beta\u2010Glucan Test. Predisposing conditions, focus of infection and other variables were retrieved from medical charts and laboratory databases. Their association with a positive BDG test, and the association between positive BDG and death was tested in univariate analysis and multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 134 patients with candidemia. Positive BDG and a non\u2010abdominal deep\u2010seated focus of infection (e.g., hematogenously disseminated infection and deep mediastinal\/pleural candidiasis) were positively correlated in univariate and multivariable analyses [Wako adjusted odds ratio 9.11 (95% CI 1.66\u2013172,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039), Glucatell adjOR 9.14 (95% CI 1.66\u2013172,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039)]. Having a positive BDG test increased the risk for 90\u2009days mortality after controlling for potential confounders, mainly age, septic shock, and ICU admission [Wako adjOR 4.73 (95% CI 1.71\u201314.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0043), Glucatell adjOR 3.59 (95% CI 1.33\u201310.6,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015)].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with candidemia, a positive BDG test is more common in the presence of a concomitant non\u2010abdominal deep\u2010seated infection. Patients with a positive BDG test have a higher 90\u2010day mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.70067","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T08:36:55Z","timestamp":1747039015000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["\u03b2\u2010D\u2010Glucan Testing in Candidemia: Determinants of Positivity and Association With Mortality"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7446-463X","authenticated-orcid":false,"given":"Karl","family":"Oldberg","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology Infection Prevention and Control, Office for Medical Services  Lund Sweden"},{"name":"Section for Infection Medicine, Department of Clinical Sciences Lund Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Stenmark","sequence":"additional","affiliation":[{"name":"Region V\u00e4stra G\u00f6taland, Sahlgrenska University Hospital Department of Clinical Microbiology  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5859-1056","authenticated-orcid":false,"given":"Helena","family":"Hammarstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Institute of Biomedicine Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"},{"name":"Region V\u00e4stra G\u00f6taland, Sahlgrenska University Hospital Department of Infectious Diseases  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit006"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-019-05599-w"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12039"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1008"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2014.06.009"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131602"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq206"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir897"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.50.6175"},{"issue":"7","key":"e_1_2_10_11_1","article-title":"(1\u21923)\u2010\u03b2\u2010D\u2010Glucan Testing for the Detection of Invasive Fungal Infections in Immunocompromised or Critically Ill People","volume":"7","author":"White S. 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