{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:40:21Z","timestamp":1790991621410,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      The yeast\n                      <jats:italic>Candida vulturna<\/jats:italic>\n                      is a member of the\n                      <jats:italic>Candida haemulonii<\/jats:italic>\n                      species complex, like its close relative\n                      <jats:italic>Candida auris<\/jats:italic>\n                      . Members of this species complex, including\n                      <jats:italic>C. vulturna<\/jats:italic>\n                      , often display reduced susceptibility to one or more antifungal classes. Human invasive infections by\n                      <jats:italic>C. vulturna<\/jats:italic>\n                      are increasingly reported in various countries, while the first identification of this fungus, isolated from a flower, occurred less than 10\u2009years ago. The purpose of this review is to compile all reported outbreaks and cases and describe the characteristics of this emerging yeast.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      PubMed, Scopus, Web of Science and Google Scholar were reviewed for publications until April 14, 2025. Records in English were found by using the keyword\n                      <jats:italic>Candida (Candidozyma) vulturna<\/jats:italic>\n                      , and were included if cases were invasive infections.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All reported 94 cases were exclusively from the last 10\u2009years, often in Asian or Latin American countries and included three outbreaks in Brazil, Vietnam and China. Patients displayed diverse clinical characteristics with an overall low mortality rate of 18%. Most studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911) performed antifungal susceptibility testing (AFST) with microbroth dilution methods and found reduced susceptibility to azoles and amphotericin B. The\n                      <jats:italic>ERG11<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>P135S<\/jats:italic>\n                      <\/jats:sup>\n                      mutation was shown to confer azole resistance, although the mechanism behind amphotericin B resistance has not been uncovered. Identification by MALDI\u2010ToF routinely misidentified\n                      <jats:italic>C. vulturna<\/jats:italic>\n                      as\n                      <jats:italic>C. pseudohaemulonii<\/jats:italic>\n                      or\n                      <jats:italic>C. duobushaemulonii<\/jats:italic>\n                      , leaving molecular identification by ITS sequencing or whole genome sequencing as the only available methods for accurate species determination.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Although\n                      <jats:italic>C. vulturna<\/jats:italic>\n                      is still a rare yeast, cases are increasingly reported in tropical regions. The yeast has outbreak potential, in addition to reduced susceptibility to azoles and amphotericin B. Treatment with echinocandins showed favourable outcomes with a low mortality rate.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.70070","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T06:23:56Z","timestamp":1747808636000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["<i>Candida vulturna<\/i>\n                    , the Next Fungal Menace? A Narrative Review"],"prefix":"10.1111","volume":"68","author":[{"given":"Ritika","family":"Harchand","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bram","family":"Spruijtenburg","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Radboud University Medical Center  Nijmegen the Netherlands"},{"name":"Radboudumc\u2010CWZ Center of Expertise for Mycology  Nijmegen the Netherlands"},{"name":"Department of Medical Microbiology and Immunology Canisius\u2010Wilhelmina Hospital (CWZ)\/Dicoon  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eelco F. J.","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Radboud University Medical Center  Nijmegen the Netherlands"},{"name":"Radboudumc\u2010CWZ Center of Expertise for Mycology  Nijmegen the Netherlands"},{"name":"Department of Medical Microbiology and Immunology Canisius\u2010Wilhelmina Hospital (CWZ)\/Dicoon  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theun","family":"de Groot","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Radboud University Medical Center  Nijmegen the Netherlands"},{"name":"Radboudumc\u2010CWZ Center of Expertise for Mycology  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9097-9253","authenticated-orcid":false,"given":"Shivaprakash M.","family":"Rudramurthy","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3253-6080","authenticated-orcid":false,"given":"Jacques F.","family":"Meis","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Radboud University Medical Center  Nijmegen the Netherlands"},{"name":"Radboudumc\u2010CWZ Center of Expertise for Mycology  Nijmegen the Netherlands"},{"name":"Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging\u2010Associated Diseases and Excellence Centre for Medical Mycology University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046\u2010023\u201000748\u20108"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/emi.2016.49"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666\u20105247(24)00101\u20100"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560\u20107917.ES.2024.29.45.2400729"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30609-1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.00554"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myad009"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1099\/ijsem.0.001302"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e31464"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2907.230254"},{"key":"e_1_2_9_12_1","volume-title":"Outbreak of Multidrug Resistant Candida vulturna Strains in a Neonatal ICU","author":"Lan N. P. H.","year":"2024"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2024.106349"},{"key":"e_1_2_9_14_1","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Approved Standard\u2010Third Edition: M27\u2010A3","author":"Clinical and Laboratory Standards Institute","year":"2008"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmni.2022.101012"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myad030"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2023.43.4.395"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2022.04.001"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13757"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2023.04.223"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0011453"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13756\u2010016\u20100132\u20105"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2017.09.009"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00222\u201307"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2903.221082"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00371\u201018"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01927"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens13030269"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(24)00749\u20137"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1910.130393"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12754"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.03181\u201320"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsyr\/fox054"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.funeco.2022.101212"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.03220\u201020"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14050520"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02112\u201024"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S459600"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13404"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2609.200341"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010\u2010024\u201002229\u20106"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.118.301609"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046\u2010019\u201000404\u20100"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.03364\u201019"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics13090840"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.01528\u201323"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13655"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.70070","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/myc.70070","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.70070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:58:19Z","timestamp":1789171099000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.70070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/myc.70070"],"URL":"https:\/\/doi.org\/10.1111\/myc.70070","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2025-04-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70070"}}