{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:16:05Z","timestamp":1789172165850,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fungal keratitis is a significant cause of ocular morbidity globally. There is a lack of contemporary local data in Western Australia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective chart review of fungal keratitis cases at two tertiary hospitals in Perth, Western Australia identified between 1 January 2006 and 31 December 2022. Data on patient demographics, isolated organisms, risk factors, clinical features, outcomes, and management were collected and analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 68 cases of clinically significant fungal keratitis with positive culture results from corneal scrapes. The most commonly isolated pathogens were\n                      <jats:italic>Fusarium<\/jats:italic>\n                      species (37%),\n                      <jats:italic>Candida<\/jats:italic>\n                      species (28%),\n                      <jats:italic>Scedosporium<\/jats:italic>\n                      species (10%), and\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      species (9%). The most common predisposing risk factors were prior use of topical corticosteroids (40%), contact lens wear (35%), ocular surface disease (without a corneal graft) (25%), ocular trauma (including organic matter exposure) (18%), and a previous corneal graft procedure (16%). Corneal perforation occurred in 25% of cases. A high proportion, 22 episodes in 18 eyes (26%), of patients required therapeutic penetrating keratoplasty, and 6% required evisceration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Results were largely consistent with previous studies in the Australian context.\n                      <jats:italic>Fusarium<\/jats:italic>\n                      species and\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Candida albicans<\/jats:italic>\n                      <\/jats:styled-content>\n                      were the most common pathogens isolated. Prior topical corticosteroid use was the most common predisposing risk factor, followed closely by contact lens wear and ocular surface disease. A large proportion of patients experienced corneal perforations and required penetrating keratoplasty.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.70071","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T08:09:07Z","timestamp":1747987747000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Retrospective Review of Fungal Keratitis at Two Tertiary Hospitals in Perth, Western Australia Between 2006 and 2022"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9943-7207","authenticated-orcid":false,"given":"Harry","family":"Hohnen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Royal Perth Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishant","family":"Davidoss","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Fremantle Hospital  Fremantle Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Wiffen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Fremantle Hospital  Fremantle Western Australia Australia"},{"name":"Lions Eye Institute  Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arron","family":"Radinger","sequence":"additional","affiliation":[{"name":"PathWest Laboratory Medicine WA, Department of Microbiology Fiona Stanley Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu Jin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Royal Perth Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianne","family":"Gardam","sequence":"additional","affiliation":[{"name":"PathWest Laboratory Medicine WA, Department of Microbiology Fiona Stanley Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Royal Perth Hospital  Perth Western Australia Australia"},{"name":"Lions Eye Institute  Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30448-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-200408000-00008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12822"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874364101913010100"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2021.12.001"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2006.01405.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.9.1103"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2018.12.003"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof7110907"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13009"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.13346"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1996.133"},{"key":"e_1_2_10_14_1","volume-title":"Principles and Procedures for Detection of Fungi in Clinical Specimens Direct Examination and Culture; Approved Guideline","author":"CLSI","year":"2021"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780310001600435"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.698780"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874364101206010110"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.14113"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2008.01879.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8478"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.02.030"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13010286"},{"issue":"3","key":"e_1_2_10_23_1","first-page":"214","article-title":"Corneal Blindness: A Global Perspective","volume":"79","author":"Whitcher J. 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