{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:42:10Z","timestamp":1782960130691,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Dermatophytosis is a chronic public health issue in India, often requiring systemic antifungals. Itraconazole (ITZ) is commonly used, but conventional forms show variable absorption. Super\u2010bioavailable itraconazole (SUBA\u2010ITZ) offers improved pharmacokinetics, though clinical comparisons are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the efficacy, safety, relapse, and recurrence rates of three oral ITZ formulations\u2014Conventional ITZ 100\u2009mg (C\u2010ITZ), SUBA\u2010ITZ 65\u2009mg, and SUBA\u2010ITZ 50\u2009mg\u2014in superficial dermatophytosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this open\u2010label, randomised study at a tertiary hospital, 150 patients with confirmed tinea corporis, cruris, or faciei were equally assigned to:\n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Group A: C\u2010ITZ 100\u2009mg BID<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Group B: SUBA\u2010ITZ 65\u2009mg BID<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Group C: SUBA\u2010ITZ 50\u2009mg BID<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><jats:p>Treatment lasted 6\u2009weeks without topical antifungals. Assessments were done at 3 and 6\u2009weeks; relapse and recurrence were monitored telephonically at 3 and 6\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All groups showed similar clinical response at 6\u2009weeks (BSA, PGA, KOH negativity), with no significant differences. At 3\u2009months, Group C had significantly lower relapse and recurrence (10.2%) than Group B (31.1%, 28.9%) and Group A (23.9%, 26.1%) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). By 6\u2009months, differences were not significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>All three itraconazole formulations demonstrated comparable short\u2010term efficacy in treating superficial dermatophytosis. These findings underscore the need for larger, long\u2010term randomised controlled trials to optimise itraconazole dosing strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.70080","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T08:08:23Z","timestamp":1750320503000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparative Efficacy of Three Oral Itraconazole Formulations in Superficial Dermatophytosis"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7097-7312","authenticated-orcid":false,"given":"Harsh","family":"Tyagi","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology School of Medical Sciences and Research, Sharda Hospital  Greater Noida Uttar Pradesh 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