{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T06:58:02Z","timestamp":1777100282614,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2025,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n \n Fungaemia due to non\u2010\n Candida<\/jats:italic>\n and non\u2010\n Cryptococcus<\/jats:italic>\n yeasts is uncommon but clinically significant, particularly in immunocompromised hosts. We aimed to describe the epidemiology, microbiology and outcomes of bloodstream infections (BSIs) caused by these organisms.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We identified all BSIs due to non\u2010\n Candida<\/jats:italic>\n and non\u2010\n Cryptococcus<\/jats:italic>\n yeasts over a 20\u2010year period using statewide laboratory and administrative health databases.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Seventy\u2010five unique episodes were identified. The most frequent genera were\n Trichosporon<\/jats:italic>\n (\n n<\/jats:italic>\n \u2009=\u200931, 41.3%),\n Rhodotorula<\/jats:italic>\n (\n n<\/jats:italic>\n \u2009=\u200926 34.7%) and\n Saccharomyces<\/jats:italic>\n (\n n<\/jats:italic>\n \u2009=\u200910, 13.3%) species. Antifungal susceptibility testing performed in 33 (44%) episodes revealed high MICs (>\u200916\u2009mg\/L) to echinocandins for\n Trichosporon<\/jats:italic>\n and\n Rhodotorula<\/jats:italic>\n species. Fluconazole MICs were universally elevated (\u200932\u2009mg\/L) in\n Rhodotorula<\/jats:italic>\n spp. but lower in\n \n Saccharomyces cerevisiae<\/jats:italic>\n <\/jats:styled-content>\n (2\u20134\u2009mg\/L). Voriconazole and posaconazole had good in\u00a0vitro activity across all genera where tested. Thirty\u2010day mortality was 22.7%, with the highest rate observed in\n \n S. cerevisiae<\/jats:italic>\n <\/jats:styled-content>\n (50.0%). Mortality was associated with malignancy (aHR 4.71, 95% CI 1.00\u201322.25), heart failure (aHR 11.31, 95% CI 1.66\u201377.14) and intensive care unit (ICU) admission (aHR 7.05, 95% CI 0.99\u201350.36). The presence of a central line may be protective (aHR 0.17, 95% CI 0.03\u20131.04).\n Rhodotorula<\/jats:italic>\n infection was associated with lower mortality on univariable analysis (HR 0.11, 95% CI 0.14\u20130.86) compared with\n Trichosporon<\/jats:italic>\n species.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Although rare, fungaemia due to non\u2010\n Candida<\/jats:italic>\n and non\u2010\n Cryptococcus<\/jats:italic>\n yeasts is associated with significant mortality and antifungal resistance. Species identification and susceptibility testing are crucial to guide treatment. Increased awareness is essential in high\u2010risk patients, particularly those with malignancy, heart failure, or requiring ICU admission.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/myc.70093","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T05:59:23Z","timestamp":1751954363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Epidemiology, Significance and Clinical Outcomes of Bloodstream Infections Caused by Non\u2010\n Candida<\/i>\n and Non\u2010\n Cryptococcus<\/i>\n Yeasts"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7262-7529","authenticated-orcid":false,"given":"Adam G.","family":"Stewart","sequence":"first","affiliation":[{"name":"Transplant and Immunocompromised Host Infectious Diseases, Infectious Diseases Division Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Harvard Medical School Boston Massachusetts USA"},{"name":"Centre for Clinical Research, Faculty of Medicine The University of Queensland, Royal Brisbane and Women's Hospital Campus Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin B.","family":"Laupland","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Services Royal Brisbane and Women's Hospital Brisbane Queensland Australia"},{"name":"Queensland University of Technology Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicity","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Services Royal Brisbane and Women's Hospital Brisbane Queensland Australia"},{"name":"Queensland University of Technology Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica A.","family":"Slavin","sequence":"additional","affiliation":[{"name":"National Centre for Infections in Cancer Peter MacCallum Cancer Centre Melbourne Australia"},{"name":"Department of Infectious Diseases Peter MacCallum Cancer Centre Melbourne Australia"},{"name":"Sir Peter MacCallum Department of Oncology The University of Melbourne Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon C.\u2010A.","family":"Chen","sequence":"additional","affiliation":[{"name":"Sydney Infectious Diseases Institute, the University of Sydney Sydney Australia"},{"name":"Department of Infectious Diseases Westmead Hospital Sydney Australia"},{"name":"Centre for Infectious Diseases and Microbiology Laboratory Services New South Wales Health Pathology, Westmead Hospital Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myw055"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2011.11.002"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0255-0857.167320"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-008-9136-x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01104-20"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01747-08"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00003-11"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1130-1406(08)70032-9"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki020"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/497832"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx045"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12852"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac559"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/653207"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000182534.19832.83"},{"key":"e_1_2_11_18_1","unstructured":"\u201cM59 Epidemiological Cutoff Values for Antifungal Susceptibility Testing \u201d(2020)."},{"key":"e_1_2_11_19_1","first-page":"9","article-title":"Fungemia due to Rare Yeasts Other Than Candida: 10\u2009Years of Single\u2010Center Experience","volume":"12","author":"Tepe D.","year":"2023","journal-title":"Mediterranean Journal of Infection, Microbes and 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