{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:31:38Z","timestamp":1779377498383,"version":"3.53.1"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to evaluate the clinical use of pentraxin 3 serum level as a biomarker for screening episodes of invasive fusariosis among high\u2010risk onco\u2010haematological patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed 63 serum samples from patients with invasive mould diseases and controls, which had been collected between 2009 and 2021 and stored at the Special Mycology Laboratory of Universidade Federal de S\u00e3o Paulo, Brazil. Material included samples from eight patients with invasive fusariosis, nine with invasive aspergillosis, and control groups comprising 20 healthy individuals, eight neutropenic patients with acute myeloid leukaemia, and eight allogeneic haematopoietic stem cell transplant recipients without any concomitant infection, and 10 neutropenic individuals who developed a microbiologically documented gram\u2010negative bacteremia. PTX3 levels were quantified using an enzyme\u2010linked immunosorbent assay (ELISA), and statistical analyses were performed using SPSS Statistics v.28.0, California USA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The optimal PTX3 detection threshold was established at 10\u2009pg\/mL, with the highest levels observed in patients with invasive aspergillosis (5532.8\u2009pg\/mL) and invasive fusariosis (3718.1\u2009pg\/mL). Healthy controls revealed PTX3 levels ranging from 109.9 to 385.7\u2009pg\/mL. Significant differences were noted among all groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), with PTX3 levels exceeding 1000\u2009pg\/mL exclusively in patients with IMDs. Notably, high PTX3 serum levels were detected in four out of the eight samples that had been collected 1\u20135\u2009days before the diagnosis of fusariosis by culture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that serum PTX3 quantification holds significant potential for screening patients with suspected invasive fusariosis among onco\u2010haematological patients, similar to its role in invasive aspergillosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.70095","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T06:50:23Z","timestamp":1753858223000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pentraxin 3 as a Potential Biomarker of Invasive Fusariosis in Onco\u2010Haematological Patients"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0959-8180","authenticated-orcid":false,"given":"Larissa Sim\u00e3o","family":"Gandolpho","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Escola Paulista de Medicina\u2010Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5530-1332","authenticated-orcid":false,"given":"Elaine Cristina","family":"Francisco","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Escola Paulista de Medicina\u2010Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Antimicrobial Resistance Institute of S\u00e3o Paulo (ARIES)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7092-8830","authenticated-orcid":false,"given":"Giovanni Luis","family":"Breda","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Universidade Federal do Paran\u00e1  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6395-6849","authenticated-orcid":false,"given":"Celso","family":"Arrais\u2010Rodrigues","sequence":"additional","affiliation":[{"name":"Division of Hematology Escola Paulista de Medicina\u2010Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0793-8491","authenticated-orcid":false,"given":"Arnaldo Lopes","family":"Colombo","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Escola Paulista de Medicina\u2010Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Antimicrobial Resistance Institute of S\u00e3o Paulo (ARIES)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(17)30304\u20103"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac112"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1008"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087784"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myac049"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofae285"},{"key":"e_1_2_9_8_1","unstructured":"WHO \u201cWHO Fungal Priority Pathogens List to Guide Research Development and Public Health Action \u201d2022 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