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Multidimensional regression analyses were conducted to identify key risk factors for drug\u2010related candidiasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This pharmacovigilance study identified 259 drugs associated with candidiasis through disproportionality analysis. After exclusion through univariate regression and LASSO regression, the final multivariable logistic regression analysis included 1526 candidiasis cases and 200,173 non\u2010cases (control), revealing that female gender, older age (\u2265\u200965\u2009years) and 32 specific drugs were independent risk factors for drug\u2010related candidiasis. These drugs primarily included monoclonal antibodies (6\/32), antibiotics (4\/32), glucocorticoids (4\/32) and chemotherapy agents (4\/32). Affected patients exhibited distinct clinical outcomes, with mortality\u2010related regression analysis further revealing a significant association for these drug classes. Notably, five drugs, cytarabine, etoposide, prednisone, prednisolone and dexamethasone, exhibited dual associations as both independent susceptibility factors and mortality risk factors in drug\u2010candidiasis progression. Our temporal analysis suggested enhanced clinical vigilance during the first month following the administration of these drugs to facilitate early infection detection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings offer critical references for developing risk stratification frameworks in clinical practice, and establish priority targets for future research into the pathogenesis and mortality mechanisms of this infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.70106","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T11:15:26Z","timestamp":1756293326000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Drug\u2010Related Candidiasis Risk Profiling: A Real\u2010World Pharmacovigilance Study Leveraging the <scp>FDA<\/scp> Adverse Event Reporting System 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