{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:06:10Z","timestamp":1793297170527,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009930","name":"Basilea Pharmaceutica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009930","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010643","name":"Cidara Therapeutics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010643","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014471","name":"Mundipharma Research Limited","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014471","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2025,9]]},"abstract":"ABSTRACT<\/jats:title>Background<\/jats:title>Rezafungin, a novel echinocandin with once\u2010weekly intravenous dosing, offers potential advantages for outpatient parenteral antifungal therapy (OPAT) in invasive candidiasis (IC). While clinical trial data support its efficacy and safety, real\u2010world experience remains limited.<\/jats:p><\/jats:sec>Methods<\/jats:title>A retrospective analysis of patients treated with rezafungin across Germany, Italy, Spain, and the United States between January 2024 and June 2025 was conducted. Data was collected via the FungiScope registry. Clinical characteristics, indications for rezafungin, outcomes, safety, and logistical aspects of administration were evaluated.<\/jats:p><\/jats:sec>Results<\/jats:title>Fifteen patients were included, fourteen with IC; one with chronic pulmonary aspergillosis. Regarding patients with IC, the median age was 65.5\u2009years; 43% were female. The most frequently identified pathogens were Candida glabrata<\/jats:italic> (57%) and Candida parapsilosis<\/jats:italic><\/jats:styled-content> (21%). Primary indications for rezafungin were intravascular (36%) and osteoarticular infections (36%). Rezafungin was mainly selected to enable OPAT (86%) or due to fluconazole resistance (36%) or drug\u2013drug interactions (14%). The median treatment duration was 9\u2009weeks (range: 1\u201338\u2009weeks). One mild adverse event occurred (cutaneous photosensitivity), but rezafungin was otherwise well tolerated. Complete clinical or mycological response was observed in 36% at day 30, and partial response in 50% of patients. Access differed substantially across centres due to administrative and reimbursement hurdles, affecting treatment transition to rezafungin in 71% of patients with IC.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Rezafungin was effective and well tolerated in this cohort, particularly in patients requiring long\u2010term treatment. Administrative and logistical hurdles remain significant barriers to its widespread use. Facilitated access and enhanced awareness may improve patient outcomes by supporting early initiation and continuity of care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.70114","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T07:15:50Z","timestamp":1758093350000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Rezafungin Utilisation in Real Life\u2014FungiScope<\/scp> Results From Europe and the United States"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6222-0418","authenticated-orcid":false,"given":"Ilana","family":"Reinhold","sequence":"first","affiliation":[{"name":"Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging\u2010Associated Diseases (CECAD), Faculty of Medicine University of Cologne Cologne Germany"},{"name":"Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Faculty of Medicine University of Cologne, University Hospital Cologne Cologne Germany"},{"name":"German Centre for Infection Research (DZIF), Partner Site Bonn\u2010Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0399-2220","authenticated-orcid":false,"given":"Giovanni","family":"Mori","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Santa Chiara Hospital, Azienda Provinciale per i Servizi Sanitari Trento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4674-4772","authenticated-orcid":false,"given":"Massimiliano","family":"Lanzafame","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Santa Chiara Hospital, Azienda Provinciale per i Servizi Sanitari Trento Italy"},{"name":"Centre for Medical Sciences (CISMed) University of Trento Trento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7995-5528","authenticated-orcid":false,"given":"Alessandro","family":"Limongelli","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Health Sciences (DISSAL) University of Genova Genova Italy"},{"name":"IRCCS Ospedale Policlinico San Martino Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0697-3992","authenticated-orcid":false,"given":"Antonio","family":"Vena","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Health Sciences (DISSAL) University of Genova Genova Italy"},{"name":"IRCCS Ospedale Policlinico San Martino Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5003-7821","authenticated-orcid":false,"given":"Julia","family":"G\u00f6tz","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine, Division of Infectious Diseases University of Cologne, Faculty of Medicine, University Clinics Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stilla","family":"Bauernfeind","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Regensburg, Abt. 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