{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:30:33Z","timestamp":1787985033181,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Computed tomography (CT) plays a critical role in the early detection and diagnosis of pulmonary invasive mould infection. This study aimed to compare the CT findings of proven invasive pulmonary aspergillosis (IPA) and proven pulmonary mucormycosis (PM) and develop a clinical scoring system based on CT features to differentiate PM from IPA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medical records of the pathology database among adult patients (aged \u2265\u200918\u2009years) diagnosed with proven IPA or PM between January 2003 and June 2024 were retrospectively reviewed, according to the 2020 European Organisation for Research and Treatment of Cancer criteria. CT scans were reviewed by an experienced radiologist. The primary outcome was CT findings in PM and IPA. We investigated and compared the thoracic CT findings between PM and IPA to identify the predictors of PM compared to IPA prior to invasive diagnostic procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 94 patients were included (60 with IPA and 34 with PM). The most common underlying conditions were malignancy (53.2%) and transplantation (47.9%). In univariable analysis, CT features significantly associated with PM, compared to IPA (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), included representative lesion size \u2265\u20094\u2009cm (odds ratio [OR] 3.61, 95% CI 1.48\u20138.79), consolidation (OR 5.56, 95% CI 1.52\u201320.38), halo sign (OR 3.33, 95% CI 1.39\u20138.02), reverse halo sign (RHS) (OR 6.73, 95% CI 2.39\u201318.98) and airway\u2010invasive lesion (OR 0.32, 95% CI 0.13\u20130.78). In multivariate analysis, representative lesion size \u2265\u20094\u2009cm, RHS, and airway\u2010invasive lesion were identified as independent predictors of PM, compared to IPA. These three factors were incorporated into a point\u2010based scoring system (representative lesion size \u2265\u20094\u2009cm\u2009=\u200911 points; RHS\u2009=\u2009score 17 points; airway\u2010invasive lesion\u2009=\u2009\u221212 points). A total score of &gt;\u20098 differentiated PM from IPA with 70.6% sensitivity and 78.3% specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CT findings of large consolidative lesions, the presence of a reverse halo sign, and the absence of airway invasion may aid in the early differentiation of PM from IPA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.70115","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T06:37:18Z","timestamp":1758782238000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["CT Findings for Differentiating Pulmonary Mucormycosis From Invasive Pulmonary Aspergillosis, Prior to Invasive Procedure Such as a Biopsy or Surgery: A 22\u2010Year Single\u2010Center Experience"],"prefix":"10.1111","volume":"68","author":[{"given":"Hyeon Mu","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Centre University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Asan Medical Centre University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Yun","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Centre University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eui\u2010Jin","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Centre University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seongman","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Centre University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwon","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Centre University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Jae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Centre University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Pil","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Centre University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Centre University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Oh","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Centre University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Centre University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Han","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Centre University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/375822"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1855"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/430710"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit929"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.03.019"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof6040265"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2462070712"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.193.2.7972747"},{"issue":"6","key":"e_1_2_8_11_1","first-page":"444","article-title":"High\u2010Resolution Computed Tomography and Pathologic Findings in Pulmonary Aspergillosis: A Pictorial Essay","volume":"47","author":"Logan P. M.","year":"1996","journal-title":"Canadian Association of Radiologists Journal"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2018.03.009"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0037\u2010198x(96)80043\u20105"},{"key":"e_1_2_8_14_1","volume-title":"Goldman's Cecil Medicine, Expert Consult Premium Edition\u2014Enhanced Online Features and Print, Single Volume, 24","author":"Cecil R. L. F.","year":"2012"},{"key":"e_1_2_8_15_1","unstructured":"R.Pfleger K.Kumar D.Bell et\u00a0al. \u201cPulmonary Mucormycosis \u201dReference article Radiopaedia.org accessed January 22 2025 https:\/\/doi.org\/10.53347\/rID\u201028658."},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.184.3.01840746"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.17.18792"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.931162"},{"issue":"1","key":"e_1_2_8_19_1","first-page":"29","article-title":"Laryngotracheal Mucormycosis: Report of a Case","volume":"95","author":"Mattioni J.","year":"2016","journal-title":"Ear, Nose, & Throat Journal"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00000709"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.81.5.653"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2019.02.005"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1086\/651262"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1710.110087"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.4178\/epih\/e2014017"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.57187\/s.3730"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46548\u20100"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13484"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.70115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T13:39:32Z","timestamp":1759153172000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.70115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/myc.70115"],"URL":"https:\/\/doi.org\/10.1111\/myc.70115","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70115"}}