{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T15:15:56Z","timestamp":1771341356409,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004612","name":"Funda\u00e7\u00e3o Arauc\u00e1ria","doi-asserted-by":"publisher","award":["113\/2020"],"award-info":[{"award-number":["113\/2020"]}],"id":[{"id":"10.13039\/501100004612","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["312811\/2018\u20107"],"award-info":[{"award-number":["312811\/2018\u20107"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["312222\/2021\u20101"],"award-info":[{"award-number":["312222\/2021\u20101"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Cat\u2010transmitted sporotrichosis caused by\n                      <jats:italic>Sporothrix brasiliensis<\/jats:italic>\n                      is increasingly reported in the last three decades within Brazil. Recently, other South American countries like Argentina and Chile also reported cases, while the number of reported cases in Paraguay, a Brazilian neighbour, remains quite limited with 10 feline and three human cases. Importantly, early diagnosis and disease awareness facilitate effective treatment and allow strategies to prevent spread.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Here, we describe two previously reported and 11 novel human sporotrichosis cases by\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>S.\u2009brasiliensis<\/jats:italic>\n                      <\/jats:styled-content>\n                      from Paraguay, diagnosed from 2017 to 2025.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical and epidemiological data of patients were collected, fungal isolates were phenotypically analysed with microscopy, and short tandem repeat (STR) genotyping was used for species identification and to determine genetic relatedness between isolates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From the 13 human patients, 11 were diagnosed with sporotrichosis after contact with cats, while two reported ant bites as the source. All patients reported subcutaneous lesions with lymphocutaneous spread and were treated successfully, resulting in complete resolution of the lesions, despite late recognition of the disease and prior antibiotic treatment. STR genotyping revealed a unique genotype for four cases, all imported from Brazil, including the two ant\u2010associated isolates, all patients had a history of first symptoms while still in Brazil, but later after moving to Paraguay the diagnosis was made. All other isolates were allocated to the previously identified Rio de Janeiro (RJ) clade, originating from Brazil and known to be more widespread in Brazil.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Altogether, we report the probable first two cases of transmission by ants for\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>S.\u2009brasiliensis<\/jats:italic>\n                      <\/jats:styled-content>\n                      , and all cases result from direct import or spread from Brazil.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.70130","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:48:22Z","timestamp":1765975702000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Zoonotic Sporotrichosis in Paraguay: A Public Health Alert"],"prefix":"10.1111","volume":"68","author":[{"given":"Mirtha Gabriela Santacruz","family":"Silvero","sequence":"first","affiliation":[{"name":"Regional Epidemiological Laboratory, Faculty of Health Sciences National University of the East  Minga Guaz\u00fa Paraguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0272-0709","authenticated-orcid":false,"given":"Carolina Melchior","family":"do Prado","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Microbiology, Parasitology and Pathology, Biological Sciences, Department of Basic Pathology Federal University of Parana  Curitiba Brazil"},{"name":"Radboudumc\u2010CWZ Center of Expertise for Mycology  Nijmegen the Netherlands"},{"name":"Department of Medical Microbiology and Immunology Canisius\u2010Wilhelmina Hospital (CWZ)\/Dicoon  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6734-361X","authenticated-orcid":false,"given":"Bram","family":"Spruijtenburg","sequence":"additional","affiliation":[{"name":"Radboudumc\u2010CWZ Center of Expertise for Mycology  Nijmegen the Netherlands"},{"name":"Department of Medical Microbiology and Immunology Canisius\u2010Wilhelmina Hospital (CWZ)\/Dicoon  Nijmegen the Netherlands"},{"name":"Department of Medical Microbiology Radboudumc  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amiliana","family":"Pineda","sequence":"additional","affiliation":[{"name":"Dermatological Specialties Center Ministry of Public Health and Social Welfare  San Lorenzo Paraguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Aldama","sequence":"additional","affiliation":[{"name":"Dermatological Specialties Center Ministry of Public Health and Social Welfare  San Lorenzo Paraguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azucena","family":"Lezcano","sequence":"additional","affiliation":[{"name":"Dermatological Specialties Center Ministry of Public Health and Social Welfare  San Lorenzo Paraguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Leticia","family":"Ojeda","sequence":"additional","affiliation":[{"name":"Regional Epidemiological Laboratory, Faculty of Health Sciences National University of the East  Minga Guaz\u00fa Paraguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy Segovia","family":"Coronel","sequence":"additional","affiliation":[{"name":"Regional Epidemiological Laboratory, Faculty of Health Sciences National University of the East  Minga Guaz\u00fa Paraguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline Amaral","family":"Martins","sequence":"additional","affiliation":[{"name":"Zoonosis Control Center  Foz do Igua\u00e7u Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico Augusto Lacarrubba","family":"Codas","sequence":"additional","affiliation":[{"name":"Department of Infectology Tes\u00e3i Foundation  Ciudad del Este Paraguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liz","family":"Scheid","sequence":"additional","affiliation":[{"name":"Department of Infectology Tes\u00e3i Foundation  Ciudad del Este Paraguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Mar\u00eda Duarte","family":"Zacar\u00edas","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tes\u00e3i Foundation  Ciudad del Este Paraguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derlis","family":"Rojas","sequence":"additional","affiliation":[{"name":"Regional Hospital of Ciudad del Este, X Health Region Ministry of Public Health and Social Welfare  Ciudad del Este Paraguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaldo","family":"Aldama","sequence":"additional","affiliation":[{"name":"Dermatology Service Itaugu\u00e1 National Hospital  Itaugu\u00e1 Paraguay"},{"name":"Department of Dermatology, Faculty of Medical Sciences National University of Asunci\u00f3n  San Lorenzo Paraguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Buongermini","family":"Gotz","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medical Sciences National University of Asunci\u00f3n  San Lorenzo Paraguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vania Aparecida","family":"Vicente","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Microbiology, Parasitology and Pathology, Biological Sciences, Department of Basic Pathology Federal University of Parana  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3253-6080","authenticated-orcid":false,"given":"Jacques F.","family":"Meis","sequence":"additional","affiliation":[{"name":"Radboudumc\u2010CWZ Center of Expertise for Mycology  Nijmegen the Netherlands"},{"name":"Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging\u2010Associated Diseases (CECAD), Excellence Center for Medical Mycology (ECMM) University of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theun","family":"de Groot","sequence":"additional","affiliation":[{"name":"Radboudumc\u2010CWZ Center of Expertise for Mycology  Nijmegen the Netherlands"},{"name":"Department of Medical Microbiology and Immunology Canisius\u2010Wilhelmina Hospital (CWZ)\/Dicoon  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1vio","family":"Queiroz\u2010Telles","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Microbiology, Parasitology and Pathology, Biological Sciences, Department of Basic Pathology Federal University of Parana  Curitiba Brazil"},{"name":"Department of Public Health, Hospital de Cl\u00ednicas Federal University of Paran\u00e1  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0226-024X","authenticated-orcid":false,"given":"Eelco F. 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