{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:41:20Z","timestamp":1787060480312,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014690","name":"Ministerium f\u00fcr Kultur und Wissenschaft des Landes Nordrhein-Westfalen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014690","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023448","name":"Robert Koch Institut","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023448","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nitroxoline is an old antibiotic currently approved for the treatment of uncomplicated urinary tract infections. Its mode of action is based on the chelation of bivalent cations, such as zinc.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      As zinc plays a central role in the metabolism of\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      spp., we performed antifungal susceptibility testing against Nitroxoline using broth microdilution.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Overall, 13\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      isolates were tested according to the EUCAST guidance document (Guinea et\u00a0al. EUCAST, def. doc. 9.4, 2022) including two genetically proven Azole\u2010resistant strains.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The overall Minimal Inhibitory Concentration (MIC)\n                      <jats:sub>50\/90<\/jats:sub>\n                      was 0.5\u2009mg\/L.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These results correspond to excellent in\u00a0vitro activity against\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      spp.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.70131","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T10:33:14Z","timestamp":1763375594000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["In Vitro Activity of Nitroxoline (5\u2010Nitro\u20108\u2010Hydroxyquinoline) Against\n                    <i>Aspergillus<\/i>\n                    Species"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3093-8417","authenticated-orcid":false,"given":"Ada","family":"Hoffmann","sequence":"first","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), Medical Faculty and University Hospital of Cologne, University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9599-3137","authenticated-orcid":false,"given":"Oliver 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Bonn Cologne Duesseldorf (CIO ABCD), Faculty of Medicine and University Hospital Cologne, University of Cologne  Cologne Germany"},{"name":"German Centre for Infection Research (DZIF), Partner Site Bonn\u2010Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6222-0418","authenticated-orcid":false,"given":"Ilana","family":"Reinhold","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging\u2010Associated Diseases (CECAD), University of Cologne  Cologne Germany"},{"name":"Department I of Internal Medicine, Division of Infectious Diseases, Excellence Center for Medical Mycology (ECMM), and Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Faculty of Medicine and University Hospital Cologne, University of Cologne  Cologne Germany"},{"name":"German 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