{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:22:42Z","timestamp":1788394962540,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recent literature indicates a decline in rates of candidemia in the general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To analyse temporal trends in candidemia among patients with solid tumours and haematological malignancies admitted to a dedicated cancer centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed all episodes of candidemia from July 2008 to June 2020 (12\u2010year period). The incidence of candidemia was estimated as the number of new cases per 1000 patient days of hospital admission quarterly. A linear regression model was used to analyse changes in incidence rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over a 12\u2010year period a total of 212 episodes of candidemia were identified with 90 (42.5%) occurring in patients with haematological malignancies and 122 (57.5%) in patients with solid tumours. The overall incidence of candidemia was 0.49 episodes per 1000 patient\u2010days of admission per quarter. There was a significant decline in the incidence of candidemia overtime for the overall cohort (from 0.81 to 0.21 patient days per quarter,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u20090.001). This decline was statistically significant in patients with solid tumours (from 0.91 to 0.18 patient days per quarter,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u20090.001) with only a downward trend noted in patients with haematological malignancies (from 0.65 to 0.25 patient days per quarter,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.052).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We observed a global decline in episodes of candidemia in patients with malignancies mainly driven by a decrease in patients with solid tumours. Patients with haematological malignancies continue to experience considerable rates of candidemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.70136","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T10:15:31Z","timestamp":1766139331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Incidence Rates of\n                    <i>Candida<\/i>\n                    Bloodstream Infections in Patients With Malignancies in a Comprehensive Cancer Centre"],"prefix":"10.1111","volume":"68","author":[{"given":"Mohammad","family":"El\u2010Atoum","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University at Buffalo\u2014The State University of New York  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George L.","family":"Chen","sequence":"additional","affiliation":[{"name":"Stem Cell Transplantation and Cellular Therapy University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Bonnewell","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Roswell Park Comprehensive Cancer Center and Jacobs School of Medicine and Biomedical Sciences State University of New York  Buffalo New York USA"},{"name":"Department of Pathology and Laboratory Medicine Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brahm H.","family":"Segal","sequence":"additional","affiliation":[{"name":"Department of Internal and Hospital Medicine H. Lee Moffitt Cancer Center and Research Institute  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4230-3275","authenticated-orcid":false,"given":"Nikolaos G.","family":"Almyroudis","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Roswell Park Comprehensive Cancer Center and Jacobs School of Medicine and Biomedical Sciences State University of New York  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa193"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2012.10.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.26"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ1194"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120452"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/671724"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2015.11.003"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12531"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab105"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061094"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061098"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.376"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061115"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1113849"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-118-7-199304010-00003"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(99)00102-1"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199203263261301"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/171.6.1545"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199906000-00019"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1086\/651263"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6812a3"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2404.171807"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss6808a1"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1061"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab562"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac083"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1594"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.70136","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/myc.70136","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.70136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:29:49Z","timestamp":1771338589000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.70136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/myc.70136"],"URL":"https:\/\/doi.org\/10.1111\/myc.70136","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70136"}}