{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:34:20Z","timestamp":1790699660393,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Candida<\/jats:italic>\n                      (\n                      <jats:italic>Candidozyma<\/jats:italic>\n                      )\n                      <jats:italic>auris<\/jats:italic>\n                      is an emerging yeast that poses a significant global health threat due to its multidrug resistance and ability to cause healthcare\u2010associated outbreaks. Genomic surveillance is essential for monitoring spread, transmission and antifungal resistance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To report the first identification and genomic characterisation of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>C. auris<\/jats:italic>\n                      <\/jats:styled-content>\n                      in the state of Minas Gerais, Southeast Brazil, and to investigate the genetic origin and diversity, resistance\u2010associated mutations, and potential transmission dynamics during a hospital outbreak.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Eight\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>C. auris<\/jats:italic>\n                      <\/jats:styled-content>\n                      isolates were collected during a hospital outbreak in Belo Horizonte, Minas Gerais, Brazil, including clinical samples from patients and environmental samples from surfaces in the Intensive Care Unit (ICU). Epidemiological investigation, whole\u2010genome sequencing (WGS) and phylogenomic analyses were conducted to determine circulating clade, genetic diversity, outbreak origin and the presence of antifungal resistance mutations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All isolates were classified as clade IV and exhibited high genomic similarity to strains previously reported in northern Colombia (Caribbean coast). One isolate carried the\n                      <jats:italic>ERG11<\/jats:italic>\n                      Y132F mutation, associated with fluconazole resistance, but this mutation was absent in another isolate from the same patient collected 1\u2009day earlier, indicating mixed fungal populations. Environmental isolates clustered tightly with clinical strains, supporting surface\u2010mediated transmission in the ICU.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study describes the introduction and local spread of clade IV\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>C. auris<\/jats:italic>\n                      <\/jats:styled-content>\n                      in Minas Gerais, Brazil. The findings underscore the critical role of genomic surveillance in identifying resistance mechanisms, tracing transmission pathways and guiding public health responses.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.70146","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T10:11:29Z","timestamp":1770199889000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Emergence of\n                    <i>Candida<\/i>\n                    (\n                    <i>Candidozyma<\/i>\n                    )\n                    <i>auris<\/i>\n                    in Minas Gerais, Brazil: Genomic Surveillance to Guide Rapid Public Health Responses"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1477-5558","authenticated-orcid":false,"given":"Luiz Marcelo Ribeiro","family":"Tom\u00e9","sequence":"first","affiliation":[{"name":"Central Public Health Laboratory of Minas Gerais (Lacen\u2010MG) Ezequiel Dias Foundation\u2014Funed  Belo Horizonte Minas Gerais Brazil"},{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas (ICB) Universidade Federal do Rio de Janeiro (UFRJ)  Rio de Janeiro Brazil"},{"name":"Instituto Ren\u00e9 Rachou\u2014Fiocruz Minas  Belo Horizonte Minas Gerais Brazil"},{"name":"Graduate Program in Bioinformatics Universidade Federal de Minas Gerais\u2014UFMG  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhian Renato Almeida","family":"Camargo","sequence":"additional","affiliation":[{"name":"Central Public Health Laboratory of Minas Gerais (Lacen\u2010MG) Ezequiel Dias Foundation\u2014Funed  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Wesley","family":"Bastos","sequence":"additional","affiliation":[{"name":"Centro de Bioci\u00eancias Universidade Federal do Rio Grande do Norte\u2014UFRN  Natal Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara C\u00e2ndida Ferreira","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Central Public Health Laboratory of Minas Gerais (Lacen\u2010MG) Ezequiel Dias Foundation\u2014Funed  Belo Horizonte Minas Gerais Brazil"},{"name":"Instituto Ren\u00e9 Rachou\u2014Fiocruz Minas  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia Rocha","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Central Public Health Laboratory of Minas Gerais (Lacen\u2010MG) Ezequiel Dias Foundation\u2014Funed  Belo Horizonte Minas Gerais Brazil"},{"name":"Instituto Ren\u00e9 Rachou\u2014Fiocruz Minas  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00edlvia Helena Sousa Pietra","family":"Pedroso","sequence":"additional","affiliation":[{"name":"Central Public Health Laboratory of Minas Gerais (Lacen\u2010MG) Ezequiel Dias Foundation\u2014Funed  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Eduardo","family":"de Souza da Silva","sequence":"additional","affiliation":[{"name":"Central Public Health Laboratory of Minas Gerais (Lacen\u2010MG) Ezequiel Dias Foundation\u2014Funed  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arist\u00f3teles","family":"G\u00f3es\u2010Neto","sequence":"additional","affiliation":[{"name":"Graduate Program in Bioinformatics Universidade Federal de Minas Gerais\u2014UFMG  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lida Jouca","family":"de Assis Figueredo","sequence":"additional","affiliation":[{"name":"Central Public Health Laboratory of Minas Gerais (Lacen\u2010MG) Ezequiel Dias Foundation\u2014Funed  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"da C\u00f4rte Castro","sequence":"additional","affiliation":[{"name":"Central Public Health Laboratory of Minas Gerais (Lacen\u2010MG) Ezequiel Dias Foundation\u2014Funed  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria Ribeiro Nunes","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Central Public Health Laboratory of Minas Gerais (Lacen\u2010MG) Ezequiel Dias Foundation\u2014Funed  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia Ribeiro Soares","family":"Cruzeiro","sequence":"additional","affiliation":[{"name":"Secretaria de Estado de Sa\u00fade de Minas 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Dolores","family":"Faria","sequence":"additional","affiliation":[{"name":"Central Public Health Laboratory of Minas Gerais (Lacen\u2010MG) Ezequiel Dias Foundation\u2014Funed  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Giovanetti","sequence":"additional","affiliation":[{"name":"Instituto Ren\u00e9 Rachou\u2014Fiocruz Minas  Belo Horizonte Minas Gerais Brazil"},{"name":"Department of Sciences and Technologies for Sustainable Development and One Health Universita Campus Bio\u2010Medico di Roma  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Campos","family":"de Melo Iani","sequence":"additional","affiliation":[{"name":"Central Public Health Laboratory of Minas Gerais (Lacen\u2010MG) Ezequiel Dias Foundation\u2014Funed  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Carlos J\u00fanior","family":"Alcantara","sequence":"additional","affiliation":[{"name":"Instituto Ren\u00e9 Rachou\u2014Fiocruz Minas  Belo Horizonte Minas Gerais Brazil"},{"name":"CT Vacinas\u2014Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1471-0084","authenticated-orcid":false,"given":"Talita \u00c9mile Ribeiro","family":"Adelino","sequence":"additional","affiliation":[{"name":"Central Public Health Laboratory of Minas Gerais (Lacen\u2010MG) Ezequiel Dias Foundation\u2014Funed  Belo Horizonte Minas Gerais Brazil"},{"name":"Instituto Ren\u00e9 Rachou\u2014Fiocruz Minas  Belo Horizonte Minas Gerais 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