{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:53:20Z","timestamp":1774565600506,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intra\u2010abdominal candidiasis (IAC) is a severe and heterogeneous infection associated with significant morbidity and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate outcomes of IAC according to initial antifungal therapy and to identify predictors of persistent infection and 30\u2010day mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective non\u2010randomised single\u2010centre study (January 2020\u2013February 2025) evaluated adult IAC according to the initial antifungal (azoles vs. echinocandins), assessing demographics, type, location, and persistent positive cultures, re\u2010intervention, antifungal reintroduction, and 3\u2010 and 90\u2010day mortality. Multivariate logistic regression identified predictors of persistent cultures and 30\u2010day mortality, and inverse probability of treatment weighting (IPTW) addressed confounding in mortality analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 154 patients (median age 64.5\u2009years, 66.9% male), 102 received azoles and 52 echinocandins, with greater severity in the latter group. Persistent positive cultures occurred in 51.7% (46\/89), without difference between groups. Factors associated with persistent positive cultures included concomitant candidemia, septic shock, previous antibiotic usage, and peritonitis. The 30\u2010day mortality was 28.1% (higher with echinocandins, 38.5% vs. 22.8% in azole group,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041). Multivariate logistic regression and IPTW indicated that the initial antifungal therapy did not affect 30\u2010day mortality, while septic shock (OR:2.2, 95% CI:1.0\u20134.9;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047) and age\u2009\u2265\u200960\u2009years (OR:2.6, 95% CI:1.1\u20136.3;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032) were significantly associated with it.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IAC remains a complex infection with substantial morbidity and mortality. Echinocandins are preferred in critically ill patients, but mortality did not differ significantly between initial echinocandin and azole treatment. Persistent positive cultures were linked to severe presentation, including peritonitis, candidemia, and septic shock, which required more frequent re\u2010intervention, and consequently carried higher mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.70147","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:03:41Z","timestamp":1772985821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Outcomes of Intra\u2010Abdominal Candidiasis by Initial Antifungal Therapy"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3223-670X","authenticated-orcid":false,"given":"M.","family":"Albanell\u2010Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Pharmacy Service, Division of Medicines, Hospital Clinic of Barcelona Universitat de Barcelona  Barcelona Spain"},{"name":"Department of Physiological Science, School of Medicine Universitat de Barcelona, L'hospitalet de Llobregat  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5046-4490","authenticated-orcid":false,"given":"A.","family":"Vergara","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Hospital Clinic\u2010CDB Universitat de Barcelona  Barcelona Spain"},{"name":"Institute of Global Health (ISGlobal)  Barcelona Spain"},{"name":"CIBER Enfermedades Infecciosas (CIBERINFEC) Instituto Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1863-6379","authenticated-orcid":false,"given":"F.","family":"Marco","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Hospital Clinic\u2010CDB Universitat de Barcelona  Barcelona Spain"},{"name":"Institute of Global Health (ISGlobal)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5057-354X","authenticated-orcid":false,"given":"S.","family":"Herrera","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Clinic of Barcelona Universitat de Barcelona  Barcelona Spain"},{"name":"Institut D'investigaci\u00f3 Biom\u00e8dica August Pi I Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Faculty of Medicine University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9153-6956","authenticated-orcid":false,"given":"M.","family":"Tuset","sequence":"additional","affiliation":[{"name":"Pharmacy Service, Division of Medicines, Hospital Clinic of Barcelona Universitat de Barcelona  Barcelona 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